A case of spiny keratoderma associated with chronic kidney disease

Rooij, Nicholas Van; Bodapati, Sarath; Robertson, Ivan

doi:10.1111/ajd.13585

Cited by 2 publications

(2 citation statements)

References 4 publications

(6 reference statements)

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“…Of those, 41 cases had a reported history of systemic disease-13 with type II diabetes mellitus, 9,25,33,34,38,40,41,43,44,46,56,58 10 with hyperlipidemia, 18,25,39,43,53,55,56 7 with pulmonary disease including COPD and asthma, 7,14,18,21,44,47,52 and 3 with chronic kidney disease. 38,44,56 Other systemic conditions associated with SpK included pulmonary tuberculosis, 14 SARS-CoV-2 infection, 54 protein S deficiency, 5 Darier disease, 17 type IV hyperlipoproteinemia, 19 autosomal dominant polycystic kidney disease, 16 and sarcoidosis. 7 The average reported age was 47.9 in hereditary cases and 63.6 in sporadic cases.…”

Section: Resultsmentioning

confidence: 99%

“…Of the 58 articles, 10 were case series, resulting in 84 SpK cases for analysis (Table 1). The individual cases were published in the USA (32), 1,3,8,9,12,16,18,20,24,30–34,37,45,47,49,53 Spain (12), 14,22,23,26,28,29,36,39,50,54,58 Saudi Arabia (7), 10 Italy (6), 2,13,19,46,55 Japan (6), 11,21,25,40,52 Brazil (4), 5,42 United Kingdom (3), 41,57 Australia (3), 43,56 India (2), 48,51 Germany (2), 35,44 Israel (1), 27 Turkey (1), 4 France (1), 17 Scotland (1), 38 Austria (1), 15 South Africa (1), 7 and Canada (1) 6 . Of the 84 total cases, 33 (39.3%) were female and 51 (60.7%) were male.…”

Section: Resultsmentioning

confidence: 99%

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Spiny keratoderma: A review of case reports and histopathological descriptions

et al. 2023

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Spiny keratoderma (SpK) is a rare skin condition characterized by spine‐like papules on the palms and soles. The condition is identified under several names such as “music box spine keratosis” and “palmoplantar filiform hyperkeratosis,” creating ambiguity in the diagnostic and histopathologic features of the disease. In this study, we reviewed 84 cases of SpK to examine patient demographics, medical history, clinical and histopathological descriptions, and sporadic versus hereditary onset. Notably, the most used histopathological terms were “parakeratosis” and “hypogranulosis,” and the most used clinical terms were “spine” and “hyperpigmented.” The average age at presentation was 60.1 years with the majority of cases in males. Only 29.8% of cases were associated with a family history of SpK and underlying malignancies were present in 28.6% of cases. This review investigates the frequency of histopathologic and clinical terms used to describe SpK to provide insight into the clinical and histopathological characteristics of this rarely reported condition.

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