A case of small-intestinal mucosal atrophy

Risk of tuberculosis in a large sample of patients with coeliac disease - a nationwide cohort study

“…Several studies and case reports have indicated a positive association between CD and TB. [7][8][9][10][11][12] In 2007, our research group found that patients with a CD in-patient diagnosis were at a 4-fold increased risk of developing TB in the future. However, that study may have overestimated the risk of TB in CD since individuals with CD were identified using the Swedish in-patient register and not all individuals with CD require hospital admission.…”

“…[7][8][9][10][11][12][13]18 Two of these studies calculated risk estimates among patients with CD 12, 13 with rather high relative risks for both incident TB (HR = 3.74; 95% CI = 2.14-6.53) 13 and death from TB (standardised mortality ratio, SMR = 5.9; 95% CI = 1.6-15.1).…”

Collagenous sprue: a coeliac disease look-alike with different treatment strategy

“…The first reports of collagenous sprue indicated a condition with poor prognosis,10 11 but later studies draw a picture of better prognosis in part due to the earlier recognition of the condition and the initiation of treatment including immunomodulators and glucocorticoids which might be crucial for a beneficial disease outcome 3 9…”

Successful treatment of collagenous sprue with combination of prednisolone and gluten-free diet

“…Hypoalbuminaemia has been a feature of severe, and particularly fatal, cases of adult coeliac disease (Pink & Creamer, 1967;Barry et al, 1970;Weinstein et al, 1970;Doe et al, 1972;Dowling & Henry, 1972). It was a marked feature in our patient, in whom the cause was protein-losing enteropathy.…”

“…Some such patients are helped by corticosteroid therapy, but a few go on to a fatal outcome (French et al, 1957;Badenoch, 1960;Pink & Creamer, 1967). Several fatal cases have been reported in which subepithelial collagen was present in an intestinal biopsy (Schein, 1947;Hourihane, 1963;Barry, Morris & Read, 1970;Weinstein et al, 1970;Doe et al, 1972;Dowling & Henry, 1972) and it has been suggested that 'collagenous sprue' may represent a separate entity (Weinstein et al, 1970). Small foci of collagen are seen in up to 40%.…”