A case of small bowel adenocarcinoma wherein nivolumab conferred temporary benefit in disease control

Iijima, Kazutaka; Oozeki, Mitsuharu; Ikeda, Kaori; Honda, Hiroyuki; Ishibashi, Hajime; Yamaoka, Masaharu; Fujieda, Shinji; Saitoh, H; Goto, Masayuki; Araki, Masahiro; Amagai, Kenji

doi:10.1007/s12328-019-01064-9

Cited by 2 publications

(3 citation statements)

References 34 publications

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“…Positive expression of CK20, CDX2 and SATB2 is found in colorectal metastatic ovarian cancer, all of which are considered sensitive markers for colorectal tumors. Primary ovarian cancer often shows the positive expression of CK7 and MUC2/5AC, while β-catenin, CA125 and CEA also have some significance in the differential diagnosis ( 9 ). In this case, when the patient developed non-synchronized bilateral ovarian metastasis, the MDT relied mainly on the histopathology and immunohistochemistry of the lesion to diagnose the disease.…”

Section: Discussionmentioning

confidence: 99%

“…The PubMed database was searched for literature on ovarian metastasis from small bowel cancer from January 1990 to September 2023, using the following search terms: (small bowel cancer) OR (small intestine cancer) OR (jejunum cancer) OR (duodenum cancer) OR (ileum cancer) AND (metastatic ovarian cancer). Only English-language literature were selected for documented case reports of ovarian metastases from SBA and there were 10 cases (Table II) (9)(10)(11)(12)(13)(14)(15)(16)(17)(18). There are some differences between this case and cases in Table II.…”

Section: Discussionmentioning

confidence: 99%

“…Reported cases of ovarian metastasis from small bowel adenocarcinoma. also have some significance in the differential diagnosis (9). In this case, when the patient developed non-synchronized bilateral ovarian metastasis, the MDT relied mainly on the histopathology and immunohistochemistry of the lesion to diagnose the disease.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Non‑synchronous bilateral metastatic ovarian cancer originating from small bowel adenocarcinoma with multidisciplinary treatment: A case report

He,

Chen,

Zhou

et al. 2023

Oncol Lett

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Primary small bowel adenocarcinoma (SBA) is a rare gastrointestinal cancer with a low incidence of ovarian metastasis. Differential diagnosis of metastatic and primary ovarian cancer is often challenging. The present study reported the case of a 45-year-old woman with jejunal adenocarcinoma who presented with right ovarian, left ovarian, abdominopelvic implant and local recurrent bowel wall metastases successively after primary tumor resection. The ovarian masses of the patient originated from SBA, which was confirmed by immunohistochemical results. Following four comprehensive evaluations by an experienced multidisciplinary team (MDT) during the disease period, the patient underwent four operations, 28 cycles of chemotherapy, 24 cycles of targeted therapy and maintenance therapy for 8 months. As of February 2023, the patient has survived for 73 months and has a high quality of life. It is suggested that when a patient with SBA presents with an ovarian mass, the differential diagnosis between metastatic ovarian cancer and primary ovarian cancer mainly relies on immunohistochemistry. After a comprehensive evaluation by an experienced MDT, surgical resection is the primary treatment for advanced SBA, thus demonstrating some benefits for patients.

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Section: Discussionmentioning

confidence: 99%