A case of sinonasal teratocarcinosarcoma treated with surgery and post-operative intensity-modulated radiotherapy (IMRT)

Tokunaga, Tohru; Sunaga, Hiroshi; Kimura, Yuichi; Tsuda, Gota; Fujieda, Shigeharu

doi:10.1016/j.anl.2012.01.010

Cited by 7 publications

(6 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…and Peng et al . have utilized IMRT with good effect, with no recurrence at 2 and 3.5 years respectively [10, 11]. Our case supports the use of IMRT given the excellent outcome in our patient with minimal side effects 2 years post-radiotherapy.…”

Section: Discussionsupporting

confidence: 76%

Sinonasal teratocarcinosarcoma: a case report

et al. 2017

View full text Add to dashboard Cite

BackgroundSinonasal teratocarcinosarcoma is a rare and aggressive malignancy with histological features of both carcinosarcoma and teratoma. The optimal management of this malignancy is unclear, with most patients being managed by a combination of surgery and radiotherapy.Case presentationWe describe an 83-year-old white woman with sinonasal teratocarcinosarcoma of her left nasal cavity treated with surgical debulking initially with radiological evidence of residual disease which was treated with radiotherapy (60 Gy in 30 fractions). A follow-up examination at 2 years showed no evidence of recurrence.ConclusionsIn cases of sinonasal teratocarcinosarcoma with residual disease post-surgery, radiotherapy alone can be an effective option.

show abstract

Section: Discussionsupporting

confidence: 76%

Sinonasal teratocarcinosarcoma: a case report

et al. 2017

View full text Add to dashboard Cite

show abstract

“…7 Focal S100 expression in the undifferentiated component can be seen. 9,10 Focal PAX8 or diffuse expression in both the glandular and stromal component is reported. 6,9,11 ß-catenin membranous or cytoplasmic staining with or without nuclear expression can be seen.…”

Section: Discussionmentioning

confidence: 99%

Congenital Teratocarcinosarcoma With CTNNB1 Gene Mutation Presenting as an Ocular Mass

et al. 2022

View full text Add to dashboard Cite

Teratocarcinosarcoma is an extremely rare malignancy of the nasal cavity and paranasal sinuses. It exhibits both sarcomatous and carcinomatous components. Less than 100 cases are reported. It presents in adults with only two reported cases in infancy. Here we present a case of 3-week-old female with antenatally detected ocular mass. MRI revealed an exophytic right ocular mass (10 × 7.0 × 7.0 cm) with intracranial extension. The tumor consisted of malignant glands and mesenchymal elements of undifferentiated blastema-like cells and immature neuroepithelium. After an initial diagnosis and treatment for a Wilms tumor protocol, the mass showed no response. A second opinion rendered a diagnosis of sinonasal teratocarcinosarcoma. The patient underwent surgical resection and seven cycles of CNS ICE chemotherapy. A second debulking surgery revealed a very scant viable tumor with post-treatment changes. The patient is alive at 43 months on weekly vincristine maintenance. Molecular testing revealed a somatic CTNNB1 gene mutation. In conclusion, this is a rare and aggressive tumor which showed disease free survival beyond that reported in the literature with the appropriate use of multimodality therapy.

show abstract

“…However, whether this clinical advantage of IMRT can be extrapolated to SNTCS is a matter of debate as there is no trial suggesting the use of IMRT in SNCTS primarily because of the rarity of the tumor. Reports using IMRT in SNTCS with a dose prescription 60–66 Gy, reported local control ranging between 2 and 3.5 years [14-16].…”

Section: Discussionmentioning

confidence: 99%

“…Review of literature did not reveal any consensus regarding the use of elective nodal irradiation primarily because of the non-uniformity of the reported data regarding radiation fields and technique. Six reports [1,2,6,11,14,22] have commented on the use or disuse of elective nodal irradiation. Of 4 studies reporting no treatment to neck, 2 studies [2,6] have documented regional lymph node failures.…”

Section: Discussionmentioning

confidence: 99%

Sinonasal teratocarcinosarcoma treated with surgery followed by volumetric modulated radiotherapy: a case report with review of literature

et al. 2018

View full text Add to dashboard Cite

Surgical excision along with use of postoperative radiotherapy forms an integral management of sinonasal teratocarcinosarcoma (SNTCS). However, given the rarity of the tumor, no standardised guidelines, dose, technique and target delineation exist especially in the era of modern radiation delivery techniques. This is a case of 55-year-old male diagnosed as SNTCS treated with radical ethmoidectomy followed by volumetric modulated radiotherapy, showing good local control and acceptable toxicity profile.

show abstract

A case of sinonasal teratocarcinosarcoma treated with surgery and post-operative intensity-modulated radiotherapy (IMRT)

Cited by 7 publications

References 12 publications

Sinonasal teratocarcinosarcoma: a case report

Sinonasal teratocarcinosarcoma: a case report

Congenital Teratocarcinosarcoma With CTNNB1 Gene Mutation Presenting as an Ocular Mass

Sinonasal teratocarcinosarcoma treated with surgery followed by volumetric modulated radiotherapy: a case report with review of literature

Contact Info

Product

Resources

About