A case of septic arthritis caused by a Mycoplasma salivarium strain resistant towards Ciprofloxacin and Clarithromycin in a patient with chronic lymphatic leukemia

Büchsel, Martin; Pletschen, Lars; Fleiner, Michael; Häcker, Georg; Serr, Annerose

doi:10.1016/j.diagmicrobio.2016.05.018

Cited by 11 publications

(18 citation statements)

References 12 publications

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“…All three previously published cases of M. salivarium arthritis occurred in antibody deficient patients, two with a history of B cell lymphoma or leukaemia, one of which occurred as a post-operative infection in a prosthetic joint, and one with primary immunodeficiency [13–15]. It can be inferred that protective antibody is particularly important in preventing dissemination of mycoplasmas from the mucosa of the respiratory and urogenital tracts.…”

Section: Discussionmentioning

confidence: 99%

Septic polyarthritis with Mycoplasma salivarium in a patient with common variable immunodeficiency: case report and review of the literature

Totten

Xiao

Crabb

et al. 2021

Access Microbiology

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Mycoplasma salivarium is a common mycoplasma usually isolated from human oropharynx, particularly from individuals with periodontal disease. It is also among the more common mycoplasmal contaminants of eukaryotic cell cultures. Although M. salivarium has been isolated occasionally from abscesses and other sterile sites, to our knowledge, only three cases of septic arthritis have been documented in the past due to this organism, all in patients with humoral immunodeficiency. We now report a fourth case of septic polyarthritis in a patient with profound hypoimmunoglobulinemia who had experienced dental abscesses within the preceding 2 years. Our case highlights the importance of considering invasive mycoplasmal infection in hypogammaglobulinemic patients. It is likely of significance that the patient had suffered recurrent dental abscesses as a source of infection with M. salivarium .

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Section: Discussionmentioning

confidence: 99%

Septic polyarthritis with Mycoplasma salivarium in a patient with common variable immunodeficiency: case report and review of the literature

Totten

Xiao

Crabb

et al. 2021

Access Microbiology

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“…There are few publications evaluating the clinical repercussions of Ms. Among those found in research databases of the last 30 years, a higher concentration of Ms in the saliva of HIV-positive patients, 7 a case of a submassetic abscess of dental origin caused by Ms, 8 a case of arthritis in a patient with hypogammaglobulinemia, 9 a case of septic arthritis by Ms in a patient with chronic lymphoid leukemia, 10 Ms infection in an orthopedic prosthesis, 11 empyema caused by Ms 12 and two cases of Ms isolated from brain abscess 13 have been described. Similarly, all reported cases have in common the diagnostic difficulty.…”

Section: Discussionmentioning

confidence: 99%

Oral mucosa infection by Mycoplasma salivarium in a patient with chronic graft-versus-host disease: a diagnostic challenge

Bortolotti

Innocentini

Macedo

et al. 2022

Hematology, Transfusion and Cell Therapy

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“…Mycoplasma salivarium-associated septic arthritis is rare. Buchsel M et al [14] reported one case of septic arthritis due to Mycoplasma salivarium that was resistant to ciprofloxacin and clindamycin. Beeton ML et al [64] found Ureaplasma resistant to macrolides and quinolones, and Ureaplasma has a high proportion of quinolone resistance in China.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and treatment of mycoplasmal septic arthritis: a systematic review

Chen

Huang

Fang

et al. 2019

International Orthopaedics (SICOT)

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Purpose Septic arthritis caused by Mycoplasma is rare. The diagnosis and effective treatment of mycoplasmal septic arthritis remains a serious problem for clinicians. The aim of this systematic review was to document the available evidence on the diagnosis and treatment methods for mycoplasmal septic arthritis and to provide guidance for clinicians. Methods The PubMed, EMBASE, and Cochrane Library databases were searched in December 2018.The searches were limited to the English language. Article screening and data extraction and compilation were conducted by two independent reviewers. All the included studies were assessed using the Methodological Index for Non-randomized Studies (MINORS) tool. Results There was a total of 33 articles including 34 cases of mycoplasmal septic arthritis and eight of them were periprosthetic joint infection (PJI). Twenty-four patients (70.6%) were immunocompromised, and the synovial fluid white blood cell (WBC) count was significantly lower in the immunocompromised group than in the immunocompetent group (48,527 × 10 6 /L vs. 100,640 × 10 6 /L; P = 0.009). The traditional culture method took longer, and the positivity rate was lower than that of nucleic acid testing (50% vs. 100%; P = 0.016). Only 19.2% (5/26) of patients treated with empiric antibiotics were relieved of symptoms, while 82.4% (28/34) of patients achieved satisfactory results after being treated with antibiotics against Mycoplasma. Conclusion The possibility of mycoplasmal septic arthritis should be considered if patients with joint infections have a history of immunocompromised, repeated negative cultures, and poor empiric antibiotic treatment results. The rational use of nucleic acid testing technologies can help in the clinical diagnosis and treatment of mycoplasmal septic arthritis.

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A case of septic arthritis caused by a Mycoplasma salivarium strain resistant towards Ciprofloxacin and Clarithromycin in a patient with chronic lymphatic leukemia

Cited by 11 publications

References 12 publications

Septic polyarthritis with Mycoplasma salivarium in a patient with common variable immunodeficiency: case report and review of the literature

Septic polyarthritis with Mycoplasma salivarium in a patient with common variable immunodeficiency: case report and review of the literature

Oral mucosa infection by Mycoplasma salivarium in a patient with chronic graft-versus-host disease: a diagnostic challenge

Diagnosis and treatment of mycoplasmal septic arthritis: a systematic review

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