A case of sepsis caused by Streptococcus canis in a dog owner: a first case report of sepsis without dog bite in Japan

Ohtaki, Hirofumi; Ohkusu, Kiyofumi; Ohta, Hiroyuki; Miyazaki, Takashi; Yonetamari, Jun; Usui, Toshio; Mori, Ichiro; Ito, Hiroyasu; Ishizuka, Tatsuo; Seishima, Mitsuru

doi:10.1007/s10156-013-0625-6

Cited by 24 publications

(19 citation statements)

References 16 publications

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“…As an opportunistic pathogen, S. canis infections generally lead to local and self-limiting alterations of skin and mucosa, but in some cases can proceed to severe and life-threatening diseases, such as streptococcal toxic shock-like syndrome (STSLS), necrotizing fasciitis (NF), meningitis and septicemia [7][8][9][10]. S. canis can be transmitted among different host species suggesting a certain zoonotic potential [11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Homophilic protein interactions facilitate bacterial aggregation and IgG-dependent complex formation by theStreptococcus canisM protein SCM

et al. 2019

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Streptococcus canis is a zoonotic agent that causes serious invasive diseases in domestic animals and humans, but knowledge about its pathogenic potential and underlying virulence mechanisms is limited. Here, we report on the ability of certain S. canis isolates to form large bacterial aggregates when grown in liquid broth. Bacterial aggregation was attributed to the presence and the self-binding activity of SCM, the M protein of S. canis, as evaluated by bacterial sedimentation assays, immunofluorescence-and electron microscopic approaches. Using a variety of truncated recombinant SCM fragments, we demonstrated that homophilic SCM interactions occur via the N-terminal, but not the C-terminal part, of the mature M protein. Interestingly, when incubated in human plasma, SCM forms soluble protein complexes comprising its known ligands, immunoglobulin G (IgG) and plasminogen (Plg). Co-incubation studies with purified host proteins revealed that SCM-mediated complex formation is based on the interaction of SCM with itself and with IgG, but not with Plg or fibrinogen (Fbg), well-established constituents of M proteinmediated protein complexes in human-associated streptococci. Notably, these soluble, SCMmediated plasma complexes harbored complement factor C1q, which can induce complement breakdown in the periphery and therefore represent another immune evasion mechanism of SCM.

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Section: Introductionmentioning

confidence: 99%

Homophilic protein interactions facilitate bacterial aggregation and IgG-dependent complex formation by theStreptococcus canisM protein SCM

et al. 2019

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“…Most cases of Sc infection, except for dog bites, originate in pre-existing wounds and skin ulcers [12] , [13] . Notably, however, Ohtaki and colleagues recently reported the first documented human case of sepsis caused by Sc without a dog bite in Japan [14] . While the entry mechanism remains unclear, we speculate that the pathogenic Sc, which may be resident at/around the oropharynx, skin, genitourinary tract, and anal tract, seem to invade the host through invisible wounds on human skin [15] , [16] .…”

Section: Discussionmentioning

confidence: 99%

Human case of bacteremia caused by Streptococcus canis sequence type 9 harboring the scm gene

Taniyama

Abe

Sakai

et al. 2017

IDCases

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HighlightsThis is the first reported human case of bacteremia caused by Streptococcus canis having scm gene encoding M-like protein.The identity was based on similarity of its 16S rRNA and detection of the specific cfg gene encoding a co-hemolysin.This isolate was confirmed to be sequence type 9.This strain didn’t have the erm(A), erm(B), or mef(A), macrolide resistance genes, but was not susceptible to azithromycin.

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“…The isolates were sensitive to most of the tested antibiotics. There were several S. canis septicemia cases secondary to dog/cat bites or even a simple contact . Additionally, two cases of S. canis ‐infected leg wounds were published: one sepsis case in a not bitten diabetic dog owner , and another of ulcer infection in a person, whose dog had licked his leg .…”

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confidence: 99%

Human native endocarditis caused by Streptococcus canis—a case report

Mališová

Šantavý

Lovečková

et al. 2018

APMIS

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We report a very rare case of Streptococcus canis native infective endocarditis in a 73‐year‐old woman living in close contact with her dog. Her echocardiography showed large calcifications in the mitral annulus, massive regurgitation below the posterior leaflet, and adjacent vegetation. Blood culture was positive for Streptococcus Lancefield group G. A coronary artery bypass and mitral valve replacement had to be done. Streptococcus canis was detected in a heart valve using a broad range PCR followed by 16S rRNA and confirmed by tuf gene sequencing, while tissue culture remained negative. The patient was not bitten by her dog nor did she have comorbidities or skin ulcers. She fully recovered.

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A case of sepsis caused by Streptococcus canis in a dog owner: a first case report of sepsis without dog bite in Japan

Cited by 24 publications

References 16 publications

Homophilic protein interactions facilitate bacterial aggregation and IgG-dependent complex formation by theStreptococcus canisM protein SCM

Homophilic protein interactions facilitate bacterial aggregation and IgG-dependent complex formation by theStreptococcus canisM protein SCM

Human case of bacteremia caused by Streptococcus canis sequence type 9 harboring the scm gene

Human native endocarditis caused by Streptococcus canis—a case report

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