A case of resected synchronous multiple primary lung cancer comprising adenocarcinoma and carcinoid (cancer-in-cancer)

Nagamatsu, Yoshinori; Iwasaki, Yasunori; Omura, Harutaka; Kumazoe, Hiroyuki; Hyashida, Ryozo; Shirouzu, Kazuo

doi:10.1007/s11748-012-0029-z

Cited by 9 publications

(8 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pathology con rmed that the tumor in the lower lobe of the right lung was bronchial carcinoid, but the tumor in the middle lobe of the right lung was adenocarcinoma. Nagamatsu et al [13] reported in 2012 a case of adenocarcinoma found in the resection of the superior lobe of the right lung, and carcinoid was detected in the central brous scar of the adenocarcinoma. Abbi et al [14] reported a case of a tumor found during resection of the superior lobe of the right lung in 2014.…”

Section: Discussionmentioning

confidence: 99%

Lung Adenocarcinoma Complicated with a Carcinoid Microtumor: A Case Report and Literature Review

Xu¹,

He²,

Sun³

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Adenocarcinoma is the most common primary lung malignant tumor. However, pulmonary carcinoid tumorlets are rare neuroendocrine tumors, and the coexistence of adenocarcinoma and pulmonary carcinoid tumorlets is extremely rare. Herein, we describe a case of lung adenocarcinoma complicated with carcinoid tumorlets.Case presentation: A 71-year-old female patient was admitted to the hospital after physical examination, multiple micronodules were in the inferior lobe of the left lung and right lung for 2 years, and a tumor was in the superior lobe of the left lung for 1 month. The patient underwent resection of the superior lobe of the left lung and wedge resection of the inferior lobe of the left lung by Video-assisted Thoracoscopic Surgery(VATS). The pathology of the superior lobe of the left lung was adenocarcinoma (pathological stage pT1cN0M0, IA3 stage), and the pathology of the inferior lobe of the left lung was carcinoid tumorlets. The patient was discharged from the hospital one week after the operation and recovered well after follow-up without recurrence.Conclusions: The lack of understanding of carcinoid tumorlets in the clinic causes their misdiagnosis or missed diagnosis. At the same time, the lack of understand also suggests that we should pay attention not only to mass-type lung tumors but also to pulmonary micronodules.

show abstract

Section: Discussionmentioning

confidence: 99%

Lung Adenocarcinoma Complicated with a Carcinoid Microtumor: A Case Report and Literature Review

Xu¹,

He²,

Sun³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Nagamatsu et al reported a case of cancer-in-cancer and the resected specimen showed a carcinoid component localized within the central fibrous scar of the dominant adenocarcinoma component [ 12 ]. A case of five synchronous and metachronous lung cancers in a single patient that developed in a span of 7 years was reported in 2004.…”

Section: Discussionmentioning

confidence: 99%

Adenocarcinoma of Lung and Bronchial Carcinoid Presenting as Double Synchronous Primary Lung Cancer: A Case Report and Review of Literature

et al. 2018

View full text Add to dashboard Cite

Recent advances in imaging techniques led to an increase in the incidence of synchronous and metachronous primary lung cancers due to early detection. Management of these patients is challenging and prognosis depends on the stage of the tumor at initial diagnosis and histological type. A 68-year-old African American male patient with medical history of hypertension and diabetes mellitus presented to our emergency department with right sided chest pain, worsening dyspnea and dry cough of 2-week duration. He also reported significant weight loss and was a smoker with 25 pack-years smoking history. Chest radiology showed a large right pleural effusion. Subsequent thoracentesis and fluid analysis revealed a lymphocytic exudate. Patient underwent bronchoscopy with findings of an endobronchial lesion in the left lower bronchus. Microscopic analysis of the biopsy specimen showed a well differentiated carcinoid. It was decided to proceed with VATS and pleural biopsy as part of workup for unexplained exudative pleural effusion. Multiple pleural nodules were detected during the procedure and biopsy of these nodules revealed adenocarcinoma of lung. He was evaluated by Oncology and underwent palliative chemotherapy. The association of carcinoid with adenocarcinoma of lung was infrequently reported in the past. This case also highlights the importance of additional diagnostic workup for primary when the diagnosed malignancy does not explain the clinical presentation.

show abstract

“…Another possibility when considering the location of the second primary tumor is there can be a mixture of two tumors or one tumor that contains two components. Both Nagamatsu et al [5] and Sano et al [6] described this occurrence and named it "cancer in cancer" and "a mixture of two tumors", respectively. The clinical features of synchronous tumors remain unknown because they are very rare, [6] and we believe that meticulous pathological examinations are needed to reveal the presence of this mixture.…”

Section: Discussionmentioning

confidence: 99%

Carcinoid tumors of the lung and coexistence of malign epithelial tumors

Bedirhan¹

2014

Turk Gogus Kalp Dama

View full text Add to dashboard Cite

Bu çalışmada epitelyal tümörün eşlik ettiği akciğer karsinoid tümörlü ve cerrahi olarak tedavi edilen beş olgu tanımlandı ve tanısal ve patolojik incelemelere ilişkin deneyimlerimiz literatür eşliğinde tartışıldı. Ça lış m a pla nı: Akciğer epitelyal tümörünün eşlik ettiği karsinoid tümörlü beş olgu (4 erkek, 1 kadın; ort. yaş 61.8 yıl; dağılım 50-72 yıl) çalışmaya alındı. Öksürük tüm olgularda en belirgin semptom idi. Tüm olgulara ameliyat sırasında lenf nodu diseksiyonu veya lob spesifik lenf nodu diseksiyonu yapıldı. Ortalama takip süresi 30 ay (dağılım 14-72 ay) idi. Bul gu lar: Tüm olgulara anatomik rezeksiyon yapıldı. Karsinoid tümörlü dört olguda, üç karsinom tesadüfen bulundu; bunların biri bronkoskopi sırasında tespit edildi. Beşinci olguda adenokarsinom vardı ve karsinoid tümör bronkoskopi sırasında tesadüfen saptandı. Adenokarsinomlu olguda takip sırasında ikinci bir karsinom bulundu. Karsinoid tümörlerin tümü 4 ila 12 mm arasında değişen boyutlarda patolojik olarak tipik idi ve küçük hücreli dışı akciğer kanseri evresi iki olguda T 1 aN 0 ve üç olguda T 2 aN 0 idi. Şu anda tüm olgular sağ olup, 14 ila 72 aylık (ortalama 30 ay) takipte semptomsuzdur. So nuç:Akciğerin karsinoid tümörleri düşük dereceli maligniteler olup, eş zamanlı başka bir karsinoid tümör veya karsinom ile birliktelik gösterebilir. Her iki birliktelik de oldukça nadirdir ve kimi zaman ameliyatı zorlaştırabilir. Ameliyat öncesinde veya sonrasında kapsamlı bir bronkoskopik ve patolojik inceleme göğüs cerrahisinde önemlidir. Anah tar söz cük ler: Karsinoid tümör; epitelyal tümör; pulmoner neoplazm; uydu tümör. Background:In this article, we describe five cases of carcinoid tumors of the lung presenting with epithelial tumors who were surgically treated and discuss our experiences on diagnostic and pathologic examinations in the light of literature. Methods: Five cases (4 females, 1 male; mean age 61.8 years; range 50 to 72 years) of carcinoid tumors presenting epithelial tumors of the lung were enrolled in the study. Coughing was the predominant symptom in all cases. Intraoperative lymph node dissection or lobe-specific lymph node dissection were performed in all cases. The mean duration of follow-up was 30 months (range, 14 to 72 months). Results: Anatomic resections were performed in all cases. In four cases with carcinoid tumors, three carcinomas were found incidentally including one of them detected during bronchoscopy. The fifth case had an adenocarcinoma in whom the carcinoid tumor was detected incidentally during bronchoscopy. The case with an adenocarcinoma was also found to have a second carcinoma during follow-up. All carcinoid tumors were typical pathologically with a size ranging between 4 and 12 mm and stages of non-small cell lung cancer were T 1 aN 0 in two cases and T 2 aN 0 in three cases. At present, all cases are alive and symptomfree with a follow-up 14 to 72 months (mean 30 months). Conclusion:Carcinoid tumors of the lung are low-grade malignancies and may present with a synchronous tumor, which could be either anoth...

show abstract

A case of resected synchronous multiple primary lung cancer comprising adenocarcinoma and carcinoid (cancer-in-cancer)

Cited by 9 publications

References 6 publications

Lung Adenocarcinoma Complicated with a Carcinoid Microtumor: A Case Report and Literature Review

Lung Adenocarcinoma Complicated with a Carcinoid Microtumor: A Case Report and Literature Review

Adenocarcinoma of Lung and Bronchial Carcinoid Presenting as Double Synchronous Primary Lung Cancer: A Case Report and Review of Literature

Carcinoid tumors of the lung and coexistence of malign epithelial tumors

Contact Info

Product

Resources

About