A case of renal sarcoidosis with complement activation via the lectin pathway

Hagiwara, Shinji; Ohi, Hiroyuki; Eishi, Yoshinobu; Kodama, Fumiko; Tashiro, Kensuke; Makita, Yuichiro; Suzuki, Yusuke; Maeda, Kunimi; Fukui, Mitsumine; Horikoshi, Satoshi; Tomino, Yasuhiko

doi:10.1053/j.ajkd.2004.11.020

Cited by 14 publications

(7 citation statements)

References 20 publications

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“…Hagiwara et al 15 reported that a woman with pulmonary sarcoidosis had granulomatous interstitial nephritis and mesangioproliferative glomerulonephritis. Immunohistochemistry showed slight IgM and IgA deposition along capillary lesions, and C3, C4d, and C5b-9, as well as mannose-binding lectin (MBL) in mesangial lesions and capillary lesions, and DNA of Propionibacterium acnes in glomeruli.…”

Section: Discussionmentioning

confidence: 98%

IgM-immune complex glomerulonephritis associated with sarcoidosis

et al. 2006

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We present a case of proliferative glomerulonephritis with peculiar IgM deposition associated with sarcoidosis. A 62-year-old woman, who had been diagnosed with sarcoidosis 3 years previously because of abnormalities on chest X-ray radiophotographs and lymph node pathology, was admitted to our hospital for the evaluation of proteinuria and microscopic hematuria. Laboratory findings showed renal dysfunction (creatinine clearance, 52 ml/min), a moderate range of urinary protein (1.51 g/day), and increased serum lysozymes (20.7 microg/ml; normal range, 3.4-8.6 microg/ml). Serum calcium level was within the normal range. Renal biopsy revealed immune complex glomerulonephritis (IgM deposition type) with a membranoproliferative pattern, without granuloma or calcium deposition. Corticosteroid (initial dose of prednisolone [PSL], 1 mg/kg per day) was administered, but neither renal function nor urinary protein improved. She then became nephrotic and her renal function gradually deteriorated. To our knowledge, among uncommon glomerulonephritides with sarcoidosis, five cases of immune complex glomerulonephritis with IgM deposition have been reported. Immune complex glomerulonephritis with IgM deposition is unusual and could be related to sarcoidosis; it may be a characteristic pathology which could provide a clue to elucidate the pathogenesis of sarcoidosis.

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Section: Discussionmentioning

confidence: 98%

IgM-immune complex glomerulonephritis associated with sarcoidosis

et al. 2006

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“…In summary, the proteins identified reflect an ongoing inflammatory response 111,112,113 as well as an up-regulation in oxidative homeostasis 104 114-116 in the lungs of these patients. Another conclusion was that the type of proteins identified in BAL samples was mainly high abundant proteins.…”

Section: Oxidative Stress and Inflammation Responsementioning

confidence: 97%

In the Eye of the Beholder: Does the Master See the SameSpots as the Novice?

et al. 2010

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Historically, the use of two-dimensional electrophoresis (2-DE) in quantitative proteomics has been hampered by significant technical variance. Over the past decade, a range of technological leaps have reduced the overall variance of 2-DE, thus turning the technology into a robust platform for quantitative intact proteomics. However, as the confounding gel-to-gel variation improves, the variance arising from the subsequent image analysis becomes more prominent. Limitations in image alignment and spot detection of previous generations of 2-DE analysis software have demanded considerable user-intervention and manual editing, resulting in introduction of a large degree of subjectivity and software-induced variance. We evaluated the performance of SameSpots, representing a new generation of 2-DE image analysis software, using both DIGE and traditional single-stain 2-DE approaches. Evaluations of the software-induced variance in relation to other sources of variance, as well as the subjectivity through comparison of analyses performed by an expert user and a novice lab-user, were performed. In terms of statistical power, the less-experienced user achieved the better results, but no discernible difference was detected in multivariate comparisons between the users. In conclusion, we found that SameSpots represents improvements both in reproducibility and objectivity in relation to previous generations of 2-DE analysis software.

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“…Previous reports had indicated that glomerular deposits of MBL were present in the patients of postinfectious diseases and that causative pathogens were variable, such as Streptococcus [29, 30], Propionibacterium [31], Mucor [32], and hepatitis C virus [33]. In IgAN, several pathogenic viral and bacterial antigens have been proposed as being responsible for the formation of mesangial deposits of IgA and infection might trigger the onset and progression of the diseases [34, 35].…”

Section: Infection and Clinical Course Of Iga Nephropathymentioning

confidence: 99%

Pathological Scenario with the Mannose-Binding Lectin in Patients with IgA Nephropathy

Ohsawa

Ishii

Ohi

et al. 2012

Journal of Biomedicine and Biotechnology

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A deeper understanding of the mechanism of complement activation may help to elucidate the pathogenesis of IgA nephropathy (IgAN). Traditionally, the activation of an alternative pathway (AP) has been recognized as an enhancer mechanism of glomerular damage. This paper documents contemporary information concerning the possible pathological mechanisms of the lectin pathway (LP) in the circulation and in the glomerulus. The circulating initiator of LP activation is not fully understood. However, ligands for mannose-binding lectin (MBL) which are among the starter molecules of the LP are aberrant glycosylated molecules-containing immune complex. Recent reports have focused on N-glycans on secretory IgA as a candidate ligand. Mesangial deposits of MBL are seen in 25% of patients with IgAN. Mesangial deposits of MBL and C4 and/or C4 breakdown products are implicated as markers for disease progression of IgAN. On the other hand, patients with MBL deficiency tend to show better clinical presentation and lower levels of urinary protein and serum creatinine than MBL-sufficient patients. It is now recognized that involvement of AP and LP constitutes an additional mechanism for explaining the progression of IgAN.

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A case of renal sarcoidosis with complement activation via the lectin pathway

Cited by 14 publications

References 20 publications

IgM-immune complex glomerulonephritis associated with sarcoidosis

IgM-immune complex glomerulonephritis associated with sarcoidosis

In the Eye of the Beholder: Does the Master See the SameSpots as the Novice?

Pathological Scenario with the Mannose-Binding Lectin in Patients with IgA Nephropathy

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