A Case of Rapidly Progressive Diabetic Nephropathy Induced by Osimertinib
Kazunori Karasawa,
Ken-ichi Akiyama,
Taro Akihisa
et al.
Abstract:The number of patients with diabetic nephropathy is increasing worldwide and it is important to understand the underlying pathological mechanisms of the disease. In early stage diabetic nephropathy, the hyperglycemic environment leads to vascular endothelial cell damage, resulting in overexpression of vascular endothelial growth factor (VEGF) in podocytes and renal pathology of glomerular hypertrophy, glomerular basement membrane thickening, and mesangial hyperplasia. In diabetic nephropathy, renal thrombotic … Show more
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