A case of rapid deterioration in sperm quality following spinal cord injury

Das, Sangeeta; Soni, B M; Sharma, Sanjeev; Gazvani, R; Lewis‐Jones, D. I.

doi:10.1038/sj.sc.3101786

Cited by 14 publications

(10 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The deterioration of semen quality in SCI men has been reported to occur rapidly within the first 3 weeks after injury (Mallidis et al ., ; Das et al ., ). However, in the present study, there was no significant difference between the semen quality of samples collected up to 3 weeks after SCI and those collected later than 3 weeks.…”

Section: Discussionmentioning

confidence: 97%

“…A large subset of men sustains SCI during young adulthood, at an age when fatherhood has not yet been considered or still is an unfulfilled desire. Thus, SCI men may ask for cryopreservation of their semen to have peace of mind regarding the future availability of fertile semen samples (Das et al ., ; Bechoua et al ., ; Karsenty et al ., ). Some authors (Padron et al ., ; DeForge et al ., ; Brackett et al ., ,b; da Silva et al ., ) have proposed to freeze semen samples from SCI men early after injury for other reasons: difficulties and side effects with assisted ejaculation, variable sample quality, and the increased risk of genito‐urinary tract infections in the wake of neurogenic dysfunction (Padron et al ., ; DeForge et al ., ; Brackett et al ., ,b; da Silva et al ., ).…”

Section: Introductionmentioning

confidence: 98%

“…Male infertility after spinal cord injury (SCI) is characterized by erectile and ejaculatory dysfunction as well as inferior semen quality (Brackett et al ., ,b). The deterioration of semen characteristics occurs very early after SCI (Mallidis et al ., ; Das et al ., ) and mainly affects sperm motility and viability (Patki et al ., ). A large subset of men sustains SCI during young adulthood, at an age when fatherhood has not yet been considered or still is an unfulfilled desire.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cross‐sectional study of the sperm quality in semen samples from spinal cord injured men after long‐term cryopreservation

et al. 2015

View full text Add to dashboard Cite

SUMMARYThe deterioration of semen quality occurs very early after spinal cord injury (SCI). Thus, routine cryopreservation of semen early after injury has been recommended. However, there is currently a lack of data concerning the effects of long-term cryopreservation on the quality of spermatozoa from SCI men. We have therefore investigated the quality of spermatozoa from SCI men before and after long-term cryopreservation. The semen cryobank of a SCI rehabilitation center was screened for samples with a storage duration of more than 3 years, to carry out a cross-sectional study regarding the sperm quality of semen samples from SCI men. Semen quality analysis was carried out according to the WHO-Guidelines. The quality of 28 semen samples from 16 SCI men was investigated prior to and a median 11 years (95% CI 7-13 years) after cryopreservation. Prior to cryopreservation, ejaculate volume (median = 1.7 mL, 95% CI 1-3 mL) and sperm concentration (median = 106 9 10 6 /mL, 95% CI 82-132 9 10 6 /mL) were within normal limits, but total sperm motility (median = 19%, 95% CI 13-22%) and viability (median = 27%, 95% CI 19-45%) were reduced. Cryopreservation resulted in a significant (p < 0.0001) decrease in total sperm motility (median = 2.5%, 95% CI 0-4%) and viability (median = 7%, 95% CI 6-13%). There were no significant (p = 0.75) differences between the semen parameters of samples collected early (up to 3 weeks) after SCI and those collected later. Complete SCI had a significantly (p < 0.0001) negative effect on the sperm viability of the fresh semen samples, and tetraplegia had a significantly (p < 0.035) negative effect on both pre-cryopreservation sperm viability and post-cryopreservation motility. The assisted ejaculation technique had no significant (p > 0.053) effect on semen quality. Long-term cryopreservation of semen from SCI men results in essentially immotile sperm with minimal viability. Thus, routine long-term cryobanking of semen harvested early after SCI cannot be recommended.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cross‐sectional study of the sperm quality in semen samples from spinal cord injured men after long‐term cryopreservation

et al. 2015

View full text Add to dashboard Cite

show abstract

“…In addition to previously recognised contributory factors, increased cytokine activity in the seminal Values are number (%) With advances in the field of assisted reproduction techniques, the use of an invasive procedure like electroejaculation with its associated complications should be limited. Procuring a semen sample either for the purposes of cryopreservation of sperm soon after injury, before a decline in quality begins, 12 or at the time of assisted reproduction techniques appears to be the only justifiable reason for the use of electro-ejaculation in spinal cord injured men. It has also been conclusively shown that penile vibro-stimulation (PSV) technique is safer and provides semen specimens of a better quality than electro-ejaculation.…”

Section: Discussionmentioning

confidence: 99%

Does repeated electro-ejaculation improve sperm quality in spinal cord injured men?

et al. 2006

Self Cite

View full text Add to dashboard Cite

Study design: Retrospective analysis. Objectives: To assess the effect of repeated electro-ejaculation on the sperm quality in spinal cord injured men. Setting: Regional Spinal Injuries Unit, Southport, UK and Hewitt Center for Reproductive Medicine, Liverpool, UK. Method: Retrospective, observational study of men with spinal cord injuries undergoing repeated electro-ejaculation as a part of fertility treatment. Result: There was no improvement in the volume, sperm concentration, motility or the total motile count in the successive antegrade and retrograde samples following repeated electroejaculations. Conclusion: Electro-ejaculation is an invasive procedure and its use should be restricted to obtaining semen sample for carrying out assisted conception procedures only. Sponsorship: None.

show abstract

“…Several treatment options for men were introduced, including in vitro and in utero fertilization after ejaculation through vibratory stimulation or electro ejaculation [16]. Due to several case reports about quickly deteriorating semen quality after SCI, cryopreservation of sperm as soon as possible after injury was proposed by several authors [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Discussing reproductive health in spinal care, part II: fertility issues

et al. 2016

View full text Add to dashboard Cite

Purpose Due to advancing insights, discussing fertility in spinal care is an emerging topic. Studies among neurosurgeons to evaluate clinical practice about discussing fertility are non-existent. The aim of this study is to review knowledge, attitude and practice patterns regarding discussing fertility in spinal care. Methods Dutch neurosurgeons and residents were sent a mail-based questionnaire addressing attitude, knowledge and practice patterns regarding discussing fertility. Results Response rate was 62 % (compared to mean of 28 % in similar surveys) with 89 questionnaires suitable for analysis. Mean age was 42 years with 83 % of respondents being male. A quarter of respondents stated neurosurgeons are responsible to discuss fertility, with 12 % indicating to actually do this. Fertility is discussed more often with patients with cauda equina syndrome (70 %) and with men (p = 0.006). Merely 8 % of respondents stated to have adequate knowledge on fertility preservation (FP); this percentage was higher for doctors with spinal surgery as specialty (p = 0.015). In case of cauda equina syndrome, doctors with more knowledge discussed fertility more often (p = 0.002). Fifty-three percent of neurosurgeons wished to enhance their knowledge, in order to feel more comfortable to discuss fertility with their patients.Five percent indicated to have ever referred a patient to a fertility specialist. Conclusion With the exception of cauda equina syndrome, fertility is not routinely discussed in spinal care. Fertility is discussed more often with men. Recent guidelines state that discussing fertility is an essential part of good practice in spinal care. Education on fertility and FP needs to be integrated in the neurosurgical training program to create more awareness, and to enable clinicians to provide adequate information and care to the patient.

show abstract

A case of rapid deterioration in sperm quality following spinal cord injury

Cited by 14 publications

References 7 publications

Cross‐sectional study of the sperm quality in semen samples from spinal cord injured men after long‐term cryopreservation

Cross‐sectional study of the sperm quality in semen samples from spinal cord injured men after long‐term cryopreservation

Does repeated electro-ejaculation improve sperm quality in spinal cord injured men?

Discussing reproductive health in spinal care, part II: fertility issues

Contact Info

Product

Resources

About