A case of quadruple extrammary Paget^|^apos;s disease including umbilical lesion

Ogawa, Akina; Mizutani, Kentaro; Matsumoto, Yoshinari; Akita, Youichi; Watanabe, Daisuke

doi:10.5227/skincancer.28.283

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…In this study, we counted lesions from the anal, perineal, and genital areas as single lesions because they were anatomically adjacent. We reviewed six cases of quadruple EMPD, including our case, with respect to race, sex, age, site, recurrence, time to recurrence, and depth (Table 1) [2][3][4][5][6].…”

Section: Discussionmentioning

confidence: 99%

Recurrence of Quadruple Extramammary Paget’s Disease after 12 Years: A Case Report and Literature Review

Ishiguro,

Iwashita,

Abe

et al. 2024

Case Rep Dermatol

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Introduction: Extramammary Paget’s disease (EMPD) is a rare skin cancer that tends to be multicentric, with quadruple EMPD cases being scarcely reported. Case Presentation: We report the case of an 81-year-old man with heterochronous quadruple EMPD. Twelve years after total resection of vulvar EMPD, the patient developed erythematous lesions on the resection margin in the lower abdomen, umbilical region, and both axillae. Histological examination revealed that all lesions were in situ EMPD. Discussion: We reviewed six reported cases of quadruple EMPD with respect to race, sex, site, recurrence, time to recurrence, serum carcinoembryonic antigen, and depth. All patients were elderly Japanese males. In all but one case, the lesions were located in the apocrine region, which is a common site in such as the genital and axillary areas. Our case was the only heterochronous quadruple EMPD. The lesions were limited to the epidermis; therefore, they were unlikely to cause metastasis. It has been reported that the therapeutic effects of imiquimod can be expected in in situ EMPD. Therefore, quadruple EMPD may be a good indication of treatment option. Conclusion: EMPD is a disease whose pathogenesis is not yet clear; however, it is hoped that the origin and aetiology of EMPD will be elucidated from the clinical features of multiple EMPD in the future.

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Section: Discussionmentioning

confidence: 99%

Recurrence of Quadruple Extramammary Paget’s Disease after 12 Years: A Case Report and Literature Review

Ishiguro,

Iwashita,

Abe

et al. 2024

Case Rep Dermatol

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“…We searched the English and Chinese literature and summarised our cases and other 18 multiple EMPD cases previously reported (Table 1). [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] The mean age at diagnosis was 74 years. Of the 20 identified cases of multiple location EMPD, 19 were men, 17 (85%) of these men were Asian, and only 3 were caucasian, including the only female.…”

Section: Discussionmentioning

confidence: 99%

Concurrent extramammary Paget's disease involving the genitalia and axilla: Case report and literature review

Zhao

Zhang

et al. 2022

Aust J Dermatology

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Concurrent multiple primary extramammary Paget's disease (EMPD) is rare.Herein, we present two Chinese cases of concurrent primary EMPD involving both the genitalia and the axilla, and they also had a history of other malignancy.We also summarise the cases of multiple primary EMPD previously described in literature. Careful examination of all apocrine sweat gland-bearing sites and additional internal malignancies is recommended for patients with EMPD.

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A case of quadruple extrammary Paget^|^apos;s disease including umbilical lesion

Cited by 2 publications

References 5 publications

Recurrence of Quadruple Extramammary Paget’s Disease after 12 Years: A Case Report and Literature Review

Recurrence of Quadruple Extramammary Paget’s Disease after 12 Years: A Case Report and Literature Review

Concurrent extramammary Paget's disease involving the genitalia and axilla: Case report and literature review

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