Introduction:Atheroma of the facial artery is an extremely rare disease.Clinical Findings/Patient Concerns:Herein, we report an extremely rare case of an atheroma arising from the facial artery, mimicking a parotid gland tumor.Diagnoses:The preoperative diagnosis was a right-sided parotid gland tumor.Interventions:We performed removal of the right parotid gland tumor, via a modified face-lift incision.Outcomes:Histological examination of the specimen revealed an atheroma of the facial artery.Conclusion:Clinicians should consider atheroma in the differential diagnosis of tumors arising around the parotid gland.