A case of psoriatic spondyloarthritis exacerbation triggered by COVID‐19 messenger RNA vaccine

Ohmura, Shin-Ichiro; Hanai, Shiho; Ishihara, Ryuhei; Ohkubo, Yuji; Miyamoto, Toshiaki

doi:10.1111/jdv.18013

Cited by 7 publications

(7 citation statements)

References 8 publications

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“…These patients had a mean age of 43.0 ± 10.5 (range 30–58) years. All patients received two doses of mRNA-based vaccine, and a vaccination history was specified for four patients [ 7 , 8 , 10 ], of whom three (75%) received the BNT162b2 (Pfizer-BioNTech, Germany) vaccine [ 7 , 10 ] and one (25%) received the mRNA-1273 (Moderna) vaccine [ 8 ]. There were five patients (83.3%) experiencing exacerbation of preexisting PsA [ 7 – 10 ], while one patient (16.7%) experienced new onset of psoriasis and PsA [ 10 ].…”

Section: Resultsmentioning

confidence: 99%

“…There were five patients (83.3%) experiencing exacerbation of preexisting PsA [ 7 – 10 ], while one patient (16.7%) experienced new onset of psoriasis and PsA [ 10 ]. Among these patients, 66.7% ( n = 4/6) had peripheral arthritis [ 7 , 9 , 10 ], 33.3% ( n = 2/6) had spondylitis [ 8 , 9 ], and 16.7% ( n = 1/6) had enthesitis [ 8 ].…”

Section: Resultsmentioning

confidence: 99%

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Drug- or Vaccine-Induced/Aggravated Psoriatic Arthritis: A Systematic Review

Yeh,

Tsai

2024

Dermatol Ther (Heidelb)

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Introduction Drugs and vaccines have been less studied as inducing or aggravating factors for psoriatic arthritis (PsA) compared with psoriasis. Thus, the present study collected and summarized the publications to date about this issue. Methods We conducted a systematic literature search through the PubMed, Embase, and Cochrane databases to identify all reports on potential drug- and vaccine-related PsA events until 28 February 2023. Results In total, 179 cases from 79 studies were eligible for study. Drugs commonly reported include coronavirus disease 2019 (COVID-19) mRNA vaccines (6 cases), bacillus Calmette–Guerin (BCG) vaccine (3 cases), interferon (18 cases), immune-checkpoint inhibitors (ICI) (19 cases), and biologic disease-modifying antirheumatic drugs (bDMARDs) (127 cases). Drugs causing psoriasis may also induce or aggravate PsA (6 cases). BDMARD-related PsA mostly occurred in a “paradoxical” setting, in which the bDMARDs approved for the treatment of psoriasis induce or aggravate PsA. The reported latency may be delayed up to 2 years. Peripheral arthritis (82.3%) was the most common manifestation of drug- and vaccine-related PsA, followed by dactylitis (29.1%), enthesitis (23.4%), and spondyloarthritis (17.7%). Conclusions Drugs and vaccines may be implicated in the aggravation of PsA. Possible mechanisms include cytokine imbalance, immune dysregulation, or inadequate PsA treatment response compared with psoriasis. Most reports are case based without controls, so more studies are needed to further prove the causality. However, early recognition of factors causing or aggravating PsA is important to prevent the irreversible joint damage. Supplementary Information The online version contains supplementary material available at 10.1007/s13555-023-01082-z.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Drug- or Vaccine-Induced/Aggravated Psoriatic Arthritis: A Systematic Review

Yeh,

Tsai

2024

Dermatol Ther (Heidelb)

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“…After excluding 26 articles, 33 articles were retrieved, assessed and included in this review [ Table 1 ]. [ 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 ] Risk of bias was then assessed and presented in Supplementary Tables 1 and 2 .…”

Section: Resultsmentioning

confidence: 99%

New-Onset and Exacerbation of Psoriasis following COVID-19 Vaccination: A Systematic Review of Case Reports and Case Series

Arifin,

Hengky,

Widjaja

et al. 2023

Indian Journal of Dermatology

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Introduction: Although uncommon, several cases of new-onset and exacerbation of psoriasis have been reported after coronavirus disease 2019 (COVID-19) vaccination. This study aims to systematically review reports regarding new-onset and exacerbation of psoriasis to identify features related to that condition following COVID-19 vaccination. Materials and Methods: Three databases were utilised, namely, PubMed, Google Scholar, and EBSCOHost to search for literature published until June 2022. We used the following MeSH terms: “psoriasis,” “exacerbation,” “induced psoriasis,” and “COVID-19 vaccination.” The included literature must report the case/(s) of psoriasis exacerbation in previously-in-remission or induced psoriasis in individuals receiving any dose of COVID-19 vaccines regardless of the type. Results: Among 33 selected studies, an overall mean age was 57.52 ± 15.92 years. Female (n = 40; 54.8%) was more frequently reported than male (n = 33; 45.2%). In terms of vaccine types, Pfizer is the most commonly reported (49 cases; 67.1%), followed by Astra-Zeneca (13 cases; 17.8%), Moderna (10 cases; 13.7%), and CoronaVac (1 case; 1.4%). The onset of psoriasis after receiving the COVID-19 Vaccines was varied, ranging from 1 to 90 days (Mean ± SD: 15.75 ± 18.22). Plaque psoriasis was most commonly reported, followed by pustular, guttate and other types of psoriasis. Reported cases were frequently treated with topical steroids and monoclonal antibodies monotherapy. Conclusions: Although the cases of new-onset and exacerbation of psoriasis after COVID-19 vaccination is quite scarce, the possibility of occurrence should be acknowledged and managed properly; and patients should be informed, particularly ones with history of psoriasis without discouraging patients to take vaccine.

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“…To the best of our knowledge, 75 cases of individuals with exacerbation and 15 patients with new onset psoriasis, after vaccination had been reported, so far (Supplementary Table 1). Furthermore, other reports of development/exacerbation of inflammatory/psoriatic arthritis after COVID-19 vaccination had been reported in the literature (8,9). The mean latency from vaccine injection to the manifestation of a clinical exacerbation and new onset accounted for approximately 14 (10.9) days in 68 reported cases, which is approximately in line with our findings of latency of 7 days since exacerbation, or new onset are reported in 81% of cases within the first 3 weeks (Supplementary Table 1).…”

Section: Discussionmentioning

confidence: 97%

Case report: Clinical features of COVID-19 vaccine-induced exacerbation of psoriasis–A case series and mini review

et al. 2022

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Recently, COVID-19 vaccination-induced exacerbation or new-onset of psoriasis have been reported. Underlying immune pathogenesis is unclear and different mechanisms are assumed. Further, clinical- and vaccine-related features and characteristics are partly inconsistent and remain to be elucidated. To add to the understanding of COVID-19 vaccination-triggered psoriasis, we report five cases with exacerbation or new-onset of psoriasis. In our cohort, one patient experienced the new onset of psoriasis, while four had an exacerbation following COVID-19 vaccination. In most patients, exacerbation or new onset occurred after the 2nd or 3rd vaccination. The mean latency from the day of vaccination was 7.2 (1.8) days (SD). The clinical impact with a mean PASI increase following COVID-19 vaccination of 7.2 (5.6) was considered relevant. In most cases, psoriatic lesions almost cleared after applying topical steroids in addition to current treatment, while one patient with psoriatic arthritis required systemic treatment. New onset and exacerbation of psoriasis have also been noted following COVID-19 infections. Hence, the underlying inflammatory response is most likely the culprit agent triggering psoriasis. This underscores that the benefits of COVID-19 vaccination far outweigh the risks, as also in patients with psoriasis.

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A case of psoriatic spondyloarthritis exacerbation triggered by COVID‐19 messenger RNA vaccine

Cited by 7 publications

References 8 publications

Drug- or Vaccine-Induced/Aggravated Psoriatic Arthritis: A Systematic Review

Drug- or Vaccine-Induced/Aggravated Psoriatic Arthritis: A Systematic Review

New-Onset and Exacerbation of Psoriasis following COVID-19 Vaccination: A Systematic Review of Case Reports and Case Series

Case report: Clinical features of COVID-19 vaccine-induced exacerbation of psoriasis–A case series and mini review

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