A Case of Pseudomelanosis Duodeni: Striking Endoscopic Features With Subtle but Characteristic Pathologic Findings

A Rare Case of Duodenal Pseudomelanosis

“…Duodenal biopsy samples stained with routine hematoxylin and eosin (B) showed aggregates of pigment-laden macrophages in the lamina propria of the apical portion of the villi, which tested intensely positive with Perl's stain for iron; enterocytes demonstrated a faint positivity for Perl's Prussian blue underneath the microvilli (B, inset). These findings were consistent for duodenal pseudomelanosis, a benign condition which harbors no known clinical sequelae[1][2][3][4][5][6][7][8][9][10][11][12][13].…”

A Rare Case of Duodenal Melanosis: Case Report

“…This condition is defined as “pseudomelanosis” because unlike the melanosis coli, which is associated with the overuse of anthraquinone containing laxatives, PM does not contain lipofuscin [ 7 , 8 ]. The underlying cause of PM is not clear; however, multiple case reports have been published, reporting its association with certain medications such as hydralazine, ferrous sulfate, furosemide, or propranolol or with systemic diseases such as hypertension, chronic renal disease or diabetes mellitus [ 6 , 9 - 11 ]. Although it is a benign condition and produces no symptoms, it is usually diagnosed in patients who present with other symptoms that warranting endoscopic evaluation [ 12 ].…”