A Case of Proximal Tracheal Chondrosarcoma

Tracheal chondrosarcoma: A case report, systematic review, and pooled analysis

“…Endoscopic resection was significantly more common in the group developing residual or recurrent disease (75% vs. 9%, p = .001), likely due to incomplete surgical resection. All but two patients developing recurrence or progression of their disease had grossly residual disease after their definitive surgical intervention, 4,13,24,25,30,33 and the proportion of those with residual disease was significantly greater in this group compared to those not developing recurrence (75% vs. 4%, p < .001), highlighting the importance of obtaining adequate oncologic margins.…”

“…Our literature search yielded 32 English language publications describing a total of 33 patient reports 3–33 and 5 non‐English language publications reports 34–38 describing a total of 5 patients. One case report lacked significant patient data and was excluded.…”

“…For patients with contraindications to open surgical resection, radiation, and chemotherapy, observation alone after endoscopic debulking is reasonable. Three of four patients who underwent endoscopic debulking without adjuvant treatment remained relatively symptom free for up to 36 months 4,24,25,33 . Indeed, while disease free survival dropped to 58% at 5 years, disease specific survival remained above 90% (Figure 4).…”

“…Three of four patients who underwent endoscopic debulking without adjuvant treatment remained relatively symptom free for up to 36 months. 4,24,25,33 Indeed, while disease free survival dropped to 58% at 5 years, disease specific survival remained above 90% (Figure 4). This highlights the usual indolent nature of tracheal chondrosarcoma, particularly for low-grade tumors.…”