A Case of Protein C Deficiency Associated with Cerebral Infarction and Obstruction of Deep Leg and Inferior Mesenteric Veins

Abstract

Protein C, a vitamin K‐dependent protein, is a blood coagulation inhibitor. Its deficiency causes systemic thrombosis. A 31‐year‐old woman developed cerebral infarction followed by late psychomotor seizures, and thrombosis in the inferior mesenteric vein and bilateral crural veins. Her parents were first cousins. Her mother died of cerebral thrombosis in her 30's. Her elder brother died of suspected purpura fulminans immediately after birth. Her protein C activity and protein C antigen level decreased markedly and were less than 5% of those of normal controls and 0.3 μg/ml, respectively. Her father, a paternal aunt and a maternal uncle also showed a low protein C activity and protein C antigen level. This patient seems to have congenital protein C deficiency which produced thrombosis in the leg veins and the mesenteric vein, probably cerebral infarction.

Rheological study on coagulation of blood with special reference to the triggering mechanism of venous thrombus formation

“…A number of clinical risk factors that are associated with a high incidence of intravascular coagulation exist [31][32][33][34]. However, risk factors alone seem to be insufficient to stimulate the coagulation cascade in the absence of a primary triggering mechanism.…”

Congestive ischemic colitis occurring after resection of left colon cancer: 4 case series

“…Generally, occlusion of the IMV is idiopathic, due to deficiency of protein S or C, or accompanies coagulation abnormalities due to antiphospholipid antibody syndrome and presents with symptoms similar to PCC, such as mesenteric panniculitis of the colon or colitis [8][9][10]. Further, venous occlusion has been reported in a case of idiopathic mesenteric panniculitis [11].…”

Ischemic Bowel Disease and Risk of Stroke: A One-Year Follow-up Study

“…The HR for stroke among patients with ischemic bowel disease was 3·16, 1·89, and 1·51 times that of controls during the 30-, 90-, and 365-day follow-up period, respectively. Although previous literature has suggested the possibility of an association between ischemic bowel disease and stroke, most studies to date have been based on case reports emphasizing particular diseases such as Buerger's disease (8), Chagas' disease (9), Crohn's disease (10), protein C deficiency (11), Takayasu arteritis (12), segmental arterial mediolysis (13), aortic dissection (14), and systemic lupus erythematous (15). To the best of our knowledge, the present investigation is the first large-scaled study to report epidemiological profiles regarding stroke occurrence following diagnosis with ischemic bowel disease.…”