A Case of Prostatic Carcinoma with Skin Metastases

Kawashita, Eiso; Osumi, Yasushi; Nakamura, Koji; Kawakami, Kazumori; Maehara, Susumu; Usui, Tsuguru; Ishibe, Tomoyuki; Kitano, Taiji

doi:10.1159/000281105

Cited by 3 publications

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References 2 publications

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“…Chymotrypsins, including the human tissue kallikrein 7 (hK7), a secreted serine protease that catalyzes the degradation of intercellular adhesive structures in the cornified layer of the skin, may be involved in the cutaneous manifestation of this neoplasm [66, 67]. Other selectin and receptors may be implied, including the cytosolic R1881 and androgen receptors, although further studies are needed to discern the cutaneous metastatic prostate process [68, 69]. …”

Section: Discussionmentioning

confidence: 99%

A Case of Prostatic Carcinoma Manifesting as Cutaneous Facial Nodule

Esquivel-Pinto

Torres-Álvarez

Gómez-Villa

et al. 2018

Case Reports in Urology

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Prostate cancer is the second most frequently diagnosed cancer worldwide and the fifth most common cause of cancer deaths among men. Cutaneous metastasis is an uncommon phenomenon in prostatic cancer, occurring in 0.06–0.3% of cases. Case Presentation. A 56-year-old man presented to our outpatient clinic with a one-month history of a 1.5 cm in diameter, solitary, asymptomatic, purple nodule located on his upper right cheek. After biopsy, prostatic cancer metastasis was diagnosed. Discussion. A literature review revealed 59 articles documenting 71 cases of this diagnosis. The review recorded epidemiological data, including age, duration, morphology, location, and outcome of patients. Conclusions. The skin is an uncommon site for metastasis of prostate cancer, and the review showed that its presence is associated with a poor prognosis (approximately 10 months from diagnosis).

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Section: Discussionmentioning

confidence: 99%