A case of progressive systemic sclerosis/lupus overlap syndrome: Presenting with parotid swelling

A patient with overlap syndrome: systemic lupus erythematosus, dermatomyositis, and Sjögren’s syndrome – a rare overlapping diseases case report

“…3 Ramya et al described a case of a patient with overlapping symptoms of SLE, systemic scleroderma, and secondary Sjögren's syndrome who received immunosuppressive and corticosteroid therapy. 16 Recently, biologic medications have been used in refractory cases of overlap syndrome, but the ill effect of such medications is the high likelihood of disease exacerbation in these patients. [16][17][18][19][20] Itikyala et al described a syndrome of overlap between systemic lupus erythematosus and vasculitis associated with a cytoplasmic anti-neutrophil antibody; the patient is doing well after treatment with rituximab, but this entity should be recognized and requires appropriate treatment.…”

“…16 Recently, biologic medications have been used in refractory cases of overlap syndrome, but the ill effect of such medications is the high likelihood of disease exacerbation in these patients. [16][17][18][19][20] Itikyala et al described a syndrome of overlap between systemic lupus erythematosus and vasculitis associated with a cytoplasmic anti-neutrophil antibody; the patient is doing well after treatment with rituximab, but this entity should be recognized and requires appropriate treatment. 10 On the other hand, we describe a rare case of overlap between three diseases: SLE, dermatomyositis and Sjögren's syndrome, which are currently well controlled by treatment with corticosteroids and immunoglobulin infusions, while controlling the patient's general condition.…”