A Case of Primary Uterina Lymphoma Presenting with Bleeding, Pelvic Pain, and Dysmenorrhea

Miura, Lilian Yukari; Maure, Miriam Anyury Daquin; Zomer, Monica Tessmann; Ribeiro, Reitan; Cavalcanti, Teresa Cristina Santos; Kondo, William

doi:10.1155/2018/5065738

Cited by 2 publications

(2 citation statements)

References 24 publications

(27 reference statements)

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“…The final histopathological finding showed the presence of reparative changes on endometrium without lymphoproliferative neoplasm with prominent chronic reactive bilateral salpingitis. Clinically, it was a stage of infective endocarditis according to the Ann Arbor classification, since only one organ has been involved [7]. The postoperative surgical stage was FIGO stage IA.…”

Section: Case Reportmentioning

confidence: 99%

Primary endometrial extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue type

et al. 2018

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Introduction Primary lymphomas of the female genital system are rare and represent about 2% of extranodal lymphomas and about 0.5% of malignant gynecological diseases, which occur in only 0.5% of cases in the cervix and uterine body. Mucosa-associated lymphoid tissue (MALT) lymphoma represents a rare variant of the primary genital lymphoma. Case outline This paper presents the case of a 45-year-old patient who visited a gynecologist due to abnormal menstrual bleeding within the previous three years and bloody excrement between menstrual bleedings. The ultrasound examination raised doubts about endometrial polyps, thus the fractional exploratory curettage was performed. Histologically, a dense infiltration of stromal endometrium was demonstrated in the endometrium through fine-tuned lymphocytic cells that were highly positive for immunohistochemical markers CD20, CD79a, CD45, positive for CD5 in up to 5% of tumor cells, negative for Cyclin D1, CD10, and bcl-2. The proliferation marker Ki-67 was expressed in approximately 15% of the lymphocytic tumor cells. The patient's uterus and adnexa were surgically removed and she did not receive any additional therapy. After a 3.5-year follow-up, the patient has been without a relapse of the disease. Conclusion Although non-Hodgkin's lymphomas of the genital organs, especially the MALT type of non-Hodgkin's lymphoma, are extremely rare, they should also be considered as a differential diagnosis in women with menometrorrhagia and the ultrasound image of the endometrial polyps.

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Section: Case Reportmentioning

confidence: 99%

Primary endometrial extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue type

et al. 2018

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“…Uterus corpus, vagina, and vulva are less common primary positions [ 8 ]. Patients with PLFGT in early stages are often asymptomatic, and common symptoms of more advanced stages are vaginal bleeding or discharge, abdominal pain, distension, and pelvic mass [ 9 , 10 ]. In clinical practice, patients with PLFGT initially present to their gynecologists.…”

Section: Introductionmentioning

confidence: 99%

Primary lymphoma of the female genital tract masquerading as gynecological malignancy

Shi,

Li,

et al. 2024

BMC Women's Health

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Background Primary lymphoma of the female genital tract (PLFGT) is a rare malignant tumor in the female reproductive system, with a low incidence and few clinical reports. The aim of this study is to report our institutional experience with this rare malignancy and emphasize the need for increasing the awareness about PLFGT presenting with gynecologic symptoms. Methods The medical records of patients diagnosed with PLFGT from March 2014 to November 2022 in the First Affiliated Hospital of Wannan Medical College were reviewed. Histological classification and staging were based on the World Health Organization and Ann Arbor systems, respectively. Results There were 13 patients with diagnosis of PLFGT and the median length of follow-up was 31 months (0-102 months). The main clinical symptoms included postmenopausal vaginal bleeding, pelvic mass and abdominal pain. Serum LDH increased in 10 patients and serum CA125 elevated in 2 patients. The tumor of ovarian or uterine presented as solid masses in CT or MRI, and ascites was rare. The histological subtypes were diffuse large B-cell (n = 12) and follicular (n = 1) lymphoma. Tumors were located in ovary (n = 8), uterus (n = 3), and cervix (n = 2). According to the Ann Arbor staging system, 6 cases were classified as stage II and 7 cases were classified as stage IV, respectively. A total of 10 patients underwent surgery. Combination chemotherapy was used in 10 patients. Eight patients had tumor-free survival, 1 patient had recurrent disease, 3 patients died and 1 patient lost to follow-up. The median survival time was 32 months (1-102 months). Conclusion PLFGT usually presents as gynecological symptoms and solid masses in pelvis. Surgery or biopsy was the way to obtain the pathologic diagnosis, and combination chemotherapy is the efficient method for PLFGT. Making an accurate preoperative diagnosis is of paramount importance to avoid radical gynecologic surgery.

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A Case of Primary Uterina Lymphoma Presenting with Bleeding, Pelvic Pain, and Dysmenorrhea

Cited by 2 publications

References 24 publications

Primary endometrial extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue type

Primary endometrial extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue type

Primary lymphoma of the female genital tract masquerading as gynecological malignancy

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