A case of primary squamous cell carcinoma of the breast with rapid progression

Abstract

Primary squamous cell carcinoma of the breast is a rare disease for which no definite treatment or prognosis has been established. This report describes our experience with one case of primary squamous cell carcinoma of the breast that ended in death after rapid progression. The patient was a 58 year old woman who visited our hospital complaining of a growing tumor and pain in the right breast. Ultrasonographically the tumor consisted of solid tumor and a large cyst. Squamous cell carcinoma was diagnosed by fine-needle aspiration cytology. Neoadjuvant CEF was given, but the tumor continued to grow, so CEF was discontinued after one course and modified radical mastectomy was performed subsequently. There was no evidence of metastasis to lymph nodes. About 5 months post operatively CT of the head and chest X-ray demonstrated metastatic lesions in the brain and lungs. Resection of the cerebral tumor was performed. About 1 month after the operation, however, a new metastatic brain tumor was found and the patient later died.

Abscopal Benefits of Localized Radiotherapy Depend on Activated T-cell Trafficking and Distribution between Metastatic Lesions

“…This augments an understanding of the modulation of distant tumors from the primary, a phenomena recognized more than 100 years ago and termed "concomitant immunity" (41). Third, surgical removal of the primary tumor may trigger progression of existing metastatic sites, which has been seen in the clinic (27)(28)(29)(30) as well as in animal experiments (42,43) and mathematical models (44,45). With 93% of breast cancer (early stage I and II), 98% of colon cancer (stage I, II, and III), and 71% of nonsmall cell lung cancer (early stage I and II) patients undergoing surgery as a part of their treatment (46), systemic perturbation by the presumed local treatment needs to be explored further.…”

“…We integrate an extended tumorimmune interaction model (1) into the framework to simulate growth of each metastasis. This provides nonintuitive insights into how the seeding of a new metastatic site can promote the growth of a primary tumor and offers an elegant explanation of the observation of rapid progression of metastatic disease after surgical removal of a primary tumor (27)(28)(29)(30).…”

Squamous cell carcinoma of the breast: About a case

“…The diagnosis of squamous cell carcinoma of the breast is retained after having ruled out parenchymal invasion by a squamous tumor of the skin covering, the existence of a primary tumor at a distance, or the existence of another component other than squamous cell at the within the tumor [10] .…”

“…Given the usual negativity of hormone receptors, hormone therapy has little place in the therapeutic arsenal for squamous cell carcinoma of the breast [10] .…”

Carcinoma epidermoide de mama: descripción de un caso y revisión de la literatura

“…Las manifestaciones clínicas (suelen ser de naturaleza quística) y los hallazgos radiológicos, no son específicos 5,6 . El comportamiento de este tumor es también incierto: según algunos autores este tumor adopta un comportamiento agresivo comparable con el adenocarcinoma pobremente diferenciado con metástasis tempranas 7,8 . El tratamiento, según los casos publicados, se basa en la cirugía asociada a radioterapia y quimioterapia al igual que en el tratamiento de los adenocarcinomas de mama aunque algunos autores recomiendan emplear el mismo tipo de tratamiento que para los tumores escamosos de otros órganos.…”