A case of primary restless leg syndrome aggravated by pregnancy

Abstract

Restless leg syndrome (RLS) is characterized by intense restlessness and unpleasant creeping sensations deep inside the lower legs, occurring during periods of rest, evening and night. These symptoms can be improved by movement. There are two different phenotypes of RLS. One early-onset form starts before 36 years old. It has mostly a familial history, severe symptoms, and highly genetically determined. And it is a highly dependent to iron level of the brain. The other delayed-onset form starts after 36 years old, mostly secondary, without familial history, with a rapid evolution in two or three years. And it is associated with frequent low ferritin level of serum. Pathophysiology of RLS remains incompletely understood. However, advanced studies suggest that RLS may be generated by dopamine dysfunction locally within the central nervous system. Dopaminergic agonists are the treatment of choice, if the symptoms are severe. And iron therapy improves RLS symptoms in iron deprived patients. Early detection during pregnancy is needed because RLS gives an important impact on sleep efficiency and quality of life. Recently we have experienced a case of primary RLS patient diagnosed at 24+3 weeks, treated by dopaminergic agonist ropinirole and iron. We describe this case with a brief review of the literature.

Utilization of traditional herbal medicine formulas for unexplained female infertility in Korea: a retrospective study

“…These results are consistent with those of previous studies that found that JJT was the most frequently used prescription [ 20 ]. JJT is a popular prescription mainly used for menstrual disorders and female infertility, and has been studied in several case reports [ 24 – 26 ] and experimental studies [ 27 , 28 ]. BCB is a prescription for ovulation and implantation.…”

Prescription patterns of herbal medicine for polycystic ovarian syndrome in major Korean medicine hospitals: a multicenter retrospective study

“…A study evaluating the effectiveness of an herbal-based obesity management program on an obese PCOS patient concluded that Changbudodam-tang (Cangfu Daotan-tang) is effective in treating oligomenorrhea associated with obesity in PCOS [20]. Additionally, herbal prescriptions such as Chokyung-san (Tiaojing-san), Changbudodamtang (Cangfu Daotan-tang), Onkyung-tang (Wenjingtang), Gyejibokryeong-hwan (Guizhi Fuling-wan), and Chokyungjongok-tang (Tiaojing Zhongyu-tang) were found to alleviate ovulatory dysfunction and apoptosis of granulosa cells, normalize the endometrium, and improve acne vulgaris, oligomenorrhea and excess androgen-related conditions associated with female ovarian dysfunction [21][22][23]. Several studies using animal PCOS models also tested the effectiveness of major herbal medicine prescriptions, such as Chokyung-san (Tiaojing-san), Gamiguibi-tang (Jiawei Guipi-tang), and Changbudodam-tang (Cangfu Daotan-tang) [23][24][25][26][27], and presented favorable results.…”