A case of primary mucoepidermoid carcinoma of the thyroid: molecular evidence of its origin

Minagawa, Akinobu; Iitaka, Makoto; Suzuki, Makoto; Yasuda, Sadatoshi; Kameyama, Kimihiko; Shimada, Shio; Kitahama, Shinji; Wada, Shigetsugu; Katayama, Satoshi

doi:10.1046/j.1365-2265.2003.01745.x

Cited by 5 publications

(11 citation statements)

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“…Currently there are only few reported cases of metastases to the axillary lymph nodes in patients with thyroid cancer and, to our knowledge, this is the first report on metastasis to the axillary lymph nodes from follicular thyroid carcinoma. In the previously published cases, the primary tumours were mostly papillary thyroid carcinomas [ 2 - 9 ], and less frequently medullary thyroid carcinoma [ 7 ], sclerosing mucoepidermoid carcinoma with eosinophilia [ 10 ], mucin-producing poorly differentiated adenocarcinoma [ 11 ] and muco-epidermoid carcinoma [ 12 ]. In most of the previously reported cases, axillary lymph node metastases occurred in the context of disseminated disease, almost always as late recurrence.…”

Section: Discussionmentioning

confidence: 99%

Axillary node metastasis from differentiated thyroid carcinoma with hürthle and signet ring cell differentiation. A case of disseminated thyroid cancer with peculiar histologic findings

et al. 2012

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BackgroundDifferentiated thyroid cancer is usually associated with an excellent prognosis and indolent course. Distant metastases are rare events at the onset of thyroid cancer. Among these presentations, metastasis to the axillary lymph nodes is even more unusual: only few cases were previously reported in the literature; there has been no report of axillary lymph node metastasis from follicular thyroid carcinoma. Axillary lymph node metastasis generally arises in the context of disseminated disease and carries an ominous prognosis.Case presentationHere we present a case of axillary lymph node metastasis in the context of disseminated differentiated thyroid cancer. The patient underwent near total thyroidectomy and neck and axillary lymph node dissection. A histopathological diagnosis of poorly differentiated follicular carcinoma with "signet ring cells" and Hürthle cell features was established. The patient received radioactive iodine therapy and TSH suppression therapy. Subsequently his serum thyroglobulin level decreased to 44.000 ng/ml from over 100.000 ng/ml.Discussion and ConclusionCurrently there are only few reported cases of axillary node metastases from thyroid cancer, and to our knowledge, this is the first report on axillary lymph node metastasis from follicular thyroid carcinoma. "Signet ring cell" is a morphologic feature shared by both benign and, more rarely, malignant follicular thyroid neoplasm, and it generally correlates with an arrest in folliculogenesis. Our case is one of the rare "signet ring cells" carcinomas so far described.

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Section: Discussionmentioning

confidence: 99%

Axillary node metastasis from differentiated thyroid carcinoma with hürthle and signet ring cell differentiation. A case of disseminated thyroid cancer with peculiar histologic findings

et al. 2012

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“…27 The presence of stromal mucin, like those found in the present cases, may be produced by stromal fibroblasts or myofibroblasts. 11 Extracellular mucin differs from epithelial mucin and is composed of uniformly sulphated acid mucin, which is stained with mucicarmine and Alcian blue but not with PAS, with or without diastase treatment. 36 We retrieved 9 cases of primary thyroid neoplasms with extensive extracellular mucin deposition found in the literature.…”

Section: Discussionmentioning

confidence: 99%

“…24 Mucin can be seen in a wide spectrum of primary thyroid tumors including follicular neoplasms, medullary carcinoma, poorly differentiated carcinoma, papillary and undifferentiated carcinomas, and mucoepidermoid and primary mucinous carcinomas. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]19,25,26 A mucincontaining thyroglossal duct cyst in the thyroid has also been described in the literature. 27 Most of the mucin of these tumors are of intracellular location and a large amount of mucin can cause a signet-ring appearance in signet-ring cell adenoma of the thyroid gland.…”

Section: Discussionmentioning

confidence: 99%

“…36 We retrieved 9 cases of primary thyroid neoplasms with extensive extracellular mucin deposition found in the literature. [8][9][10][11][12][13][14][15][16] Of 11 cases of primary thyroid neoplasms with extensive extracellular mucin deposition, including our two cases, there were 3 cases of follicular carcinomas, 4 cases of mucinous carcinoma, 1 case of mucoepidermoid carcinoma and 3 cases of the mucinous variant of follicular adenoma. In only three previously reported cases, aspiration cytologic findings were described; 12,13,16 Case 1 of current cases and another case of follicular carcinoma reported by Kuma et al 12 described nuclear grooves (not in Case 1), inclusions, and pleomorphism, but no nuclear clearing, requiring the lesion to be distinguished from papillary carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…6,7 Several cases of stromal mucin-producing thyroid neoplasms have also been reported. [8][9][10][11][12][13][14][15][16] We report here on two additional cases of follicular adenoma with thick capsule and extensive stromal mucin deposits. Importantly, this is the first time that BRAF gene mutation analysis is performed in these types of lesions.…”

Section: Introductionmentioning

confidence: 99%

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Follicular Adenoma with Extensive Extracellular Mucin Deposition: Report on Two Cases

Kim

Cho

Piña‐Oviedo

et al. 2012

Clin Med Insights Case Rep

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We report two cases of follicular adenoma of the thyroid with extensive extracellular mucin deposition. Fine needle aspiration in Case 1 showed singly discohesive polygonal cells in a granular mucinous background. They contained abundant eosinophilic cytoplasm, nuclear irregularities, and frequent nuclear inclusions with occasional bizarre mitoses. A right lobectomy was done. In Case 2, a 47-year-old Caucasian woman with multinodular goiter had total thyroidectomy and a yellow-tan nodule was found within the right lobe. Both tumors were well-encapsulated masses with thick capsules. Each was characterized by microfollicles without papillae in a mucinous stroma. Tumor cells were positive for thyroglobulin and negative for calcitonin, CEA, galectin-3, HBME-1, and CK19. The extracellular mucin stained with Alcian-blue and colloidal iron but not with mucicarmine and D-PAS. No BRAF gene mutation was detected. Because there were neither capsular nor vascular invasions, both cases were diagnosed as follicular adenomas of the thyroid with extensive extracellular mucin deposition, which as proposed by the WHO classification can be categorized as a mucinous variant of follicular adenoma. Retrospectively, frequent nuclear inclusions and the absence of nuclear grooves in the mucin-containing background of cytologic smears and histologic sections were shared by those of mucin-producing papillary carcinoma. It is unclear whether it belongs to an existing category of thyroid neoplasm with mucin production or whether it is truly a new tumor variant. Furthermore, pathologists should pay attention to avoid misdiagnosis of this variant of follicular neoplasm that shows an overlapping cytology with that of papillary carcinoma.

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Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia in conjunction with parotid basal cell adenoma: Cytologic, histologic, and molecular features

Noor

Russell

Israel

et al. 2021

Diagnostic Cytopathology

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Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) is a rare malignancy in the thyroid: only 56 cases with histologic descriptions are reported in the literature and fewer reports describe the cytomorphology. Given the rarity of SMECE, data on the cytomorphologic and molecular features are limited. We report a case of a 53‐year‐old woman with a 5 cm left thyroid mass. Fine‐needle aspiration (FNA) revealed atypia of undetermined significance and pathology of left thyroid lobectomy specimen showed SMECE. Additionally, a left pre‐auricular lump was noted and FNA followed by left superficial parotidectomy showed basal cell adenoma. Next‐generation sequencing showed point mutations in NTRK3 and NF1. Unlike salivary gland mucoepidermoid carcinoma, MAML2 translocations are not present in SMECE. Even though it is a rare entity, awareness of SMECE of the thyroid is important. In this case report we review the cytomorphologic, histologic, and molecular features.

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A case of primary mucoepidermoid carcinoma of the thyroid: molecular evidence of its origin

Cited by 5 publications

References 11 publications

Axillary node metastasis from differentiated thyroid carcinoma with hürthle and signet ring cell differentiation. A case of disseminated thyroid cancer with peculiar histologic findings

Axillary node metastasis from differentiated thyroid carcinoma with hürthle and signet ring cell differentiation. A case of disseminated thyroid cancer with peculiar histologic findings

Follicular Adenoma with Extensive Extracellular Mucin Deposition: Report on Two Cases

Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia in conjunction with parotid basal cell adenoma: Cytologic, histologic, and molecular features

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