A Case of Primary Liposarcoma of the Liver

Kontani, Tadashi; Shimada, Kosuke; Iwakura, Shinji; Donishi, Hiroki; Tamura, Koichi; Aoki, Yozo

doi:10.3919/jjsa.68.1765

Cited by 1 publication

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“…However, Kaibori et al [35] reported that the prognosis of the resected group was significantly better than that of the unresected group in cases of primary sarcomatoid carcinoma of the liver (P = 0.001). In addition, there are some reports that long-term survival can be expected by complete resection even in cases of primary liver liposarcoma [36], which tends to show extracapsular invasion [37]. In the current situation where no other treatment methods have been established, tumor resection should be performed aggressively for the primary spindle cell tumor of the liver.…”

Section: Discussionmentioning

confidence: 99%

Primary spindle cell tumor originating from the liver that was difficult to diagnose

Ikehara¹,

Shimizu²,

Hirano³

et al. 2022

surg case rep

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Background It has been reported that hepatocellular carcinoma (HCC) with spindle cell tumor accounts for 1.8% of all HCCs, but spindle cell tumors that do not show an obvious conventional HCC are extremely rare. In this report, we describe a case of resection of a primary spindle cell tumor of the liver that was difficult to diagnose. Case presentation A 75-year-old man presented with fever and right chest pain. He was suspected of a giant primary diaphragmatic tumor of extrahepatic origin by imaging studies. The preoperative differential diagnosis included benign masses such as myxoid sarcoma and schwannoma, and we planned a diaphragmatic resection. Intraoperatively, however, dissection of the tumor from the liver was not possible, requiring an extended right posterior segmentectomy with combined resection of the diaphragm. The patient had a good postoperative course and 1 year has passed since the surgery with no recurrence. The pathology showed that the mass was located just below the hepatic capsule/parenchymal region and was adherent to the diaphragm, but there was no continuity. The morphology suggested a low-grade mesenchymal tumor such as a solitary fibrous tumor and perivascular epithelioid cell tumor, but immunostaining was negative, making the diagnosis difficult. Although some areas of high proliferative activity were observed, finally, the diagnosis of primary spindle cell tumor of the liver with smooth muscle differentiation was made based on the positive results of muscle markers such as αSMA, desmin, and h-caldesmon. Conclusions Spindle cell tumor arising from the liver is so rare that preoperative and pathological diagnosis is often difficult to reach. Although further studies are needed to elucidate and better understand this uncommon clinical entity, we consider that complete resection is necessary for the above case, which may contribute to long-term survival.

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Section: Discussionmentioning

confidence: 99%