A Case of Primary Gastric CD30-Positive Anaplastic Large-Cell Lymphoma

Abstract

Gastric CD30-positive anaplastic large-cell lymphoma is a very rare disease. It is sometimes difficult to distinguish it from undifferentiated carcinoma, sarcoma and so on. We report here on a case of primary gastric anaplastic large-cell lymphoma. A 50-yr-old woman complained of epigastric pain and severe chest pain for 1 week. The gastroendoscopic examination revealed geographic mucosal irregularities with shallow ulceration at the antrum. She underwent a total gastrectomy. The gross finding of the resected stomach was an 8×4.5 cm sized ulceroinfiltrative lesion at the pyloric antrum along the lesser curvature. The microscopic examination revealed diffuse and solid proliferations of large atypical cells with pleomorphic nuclei. Immunohistochemically, the tumor cells were positive for CD30, vimentin and CD3, and this was a finding compatible with anaplastic large-cell lymphoma. To the best of our knowledge, this is the first such reported case in Korea.

Primary Gastric ALK-negative EBV-negative Anaplastic Large Cell Lymphoma Presenting with Iron Deficiency Anemia

“…ALCL is a subgroup of NHL first described in 1985 (3). It comprises about 2-3% of NHL and 12% of T-cell NHL.…”

Primary Cutaneous Anaplastic Large Cell Lymphoma With Gastric Metastasis

“…PCALCL may spread to regional lymph nodes (LNs); however, distant metastasis is rare, with only 10%-13% of cases spreading beyond the integumentary system [ 1 , 2 ]. Gastric spread of cutaneous T-cell lymphomas is especially rare, with only a few documented cases found in the literature [ 4 ]. While the stomach is the most common site for primary extra-nodal non-Hodgkin's lymphoma (NHL) (30% of cases), the most common histological subtypes of the disseminated disease usually include diffuse large B-cell lymphoma (45%-59%) and mucosa-associated lymphoid tissue (38%-48%) [ 5 ].…”