A case of primary cutaneous malakoplakia in a cardiac transplant recipient

Elkeeb, Dena; Hopkins, Zachary; Wada, David A.; Rhoads, Jamie L W

doi:10.1016/j.jdcr.2018.09.015

Cited by 9 publications

(16 citation statements)

References 7 publications

(9 reference statements)

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“…1,2,4,5 It mainly affects the immunocompromised hosts including HIV infected patients, patients with neoplasia, transplant recipients, patients on immunosuppressive drugs or autoimmune disease, connective tissue diseases, tuberculosis, sacoidosis than healthy individuals. [1][2][3]6 It can occur in numerous organs including urinary bladder, kidney, prostate, testis, pancreas, oropharynx, thyroid gland, lymph node, retroperitoneum, lung, bone/joint, brain and skin with majority of cases occurring in genitourinary tract. 1,3,5 Cutaneous malakoplakia is a rarer entity that has predilection for the perianal and genital regions.…”

Section: Discussionmentioning

confidence: 99%

“…1,3,5 Cutaneous malakoplakia is a rarer entity that has predilection for the perianal and genital regions. 1,6 The pathogenesis of malakoplakia is not fully understood, it is thought to represent acquired bactericidal defect of macrophages associated with infection, immunosupression and or autoimmune processs. The possible hypothesis is in vitro defective bactericidal activity (process of endocytosis and intracellular bacterial digestion).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cutaneous Malakoplakia of perianal skin: Report of a rare lesion at an unusual site

Magdum¹,

Phadke²,

Pol³

et al. 2021

IJPO

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Malakoplakia is a rare chronic granulomatous inflammatory condition, commonly presenting in immunocompromised patients. It most commonly occurs in urinary tract. The cutaneous form is less frequent. Here, we report a case of cutaneous malakoplakia involving perianal skin in an immunocompetent 61-year old female diagnosed on histopathology utilizing special stains. To the best of authors’ knowledge, this is the 8case report of cutaneaous malakoplakia of perianal skin in the English literature and 3in the Indian literature.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cutaneous Malakoplakia of perianal skin: Report of a rare lesion at an unusual site

Magdum¹,

Phadke²,

Pol³

et al. 2021

IJPO

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“…A manual reference check was additionally performed to capture any further relevant articles. Excluding our report, there are only eight published cases of malakoplakia in cardiac transplant recipients 1‐8 . These are summarized in Table 1.…”

Section: Literature Reviewmentioning

confidence: 97%

“…Malakoplakia was reported to manifest between 18 days 1 and 5 years 8 following cardiac transplantation. The site of involvement was cutaneous in three cases, 1‐3 lung in one, 7 colorectal in three, 4,6,8 and just one case involved the genitourinary tract, discordant with the previously reported dominance of this site in renal transplant recipients. Three cases were associated with E coli bacteremia and in the four cases where immunosuppression agents were reported, all patients had been exposed to mycophenolate, tacrolimus, and prednisolone.…”

Section: Literature Reviewmentioning

confidence: 99%

Colonic malakoplakia in a dual stem cell and cardiac transplant recipient: A case report and literature review

Meredith

Dharan

Killen

et al. 2020

Transplant Infectious Dis

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We describe the first published case of malakoplakia in a dual stem cell and cardiac transplant recipient. In the 2 months following cardiac transplantation, our patient developed persistent diarrhea and recurrent E coli bacteremia. Biopsies obtained from areas of colonic thickening revealed malakoplakia. Despite improvement in symptoms with prolonged antimicrobial therapy and reduction of his immunosuppression, he eventually died from sepsis. Our case highlights not only the importance of the timely diagnosis of this rare disorder, but also the difficulty in determining optimal treatment duration, particularly where excision of involved areas is not possible, as data on this disease are lacking. Here we describe our case and review the available literature published on malakoplakia in the cardiac transplant population.

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“…Eine mögliche Erklärung für die extragenitale Verteilung der Läsionen, wäre eine Inokulation vom Damm aus, die Assoziation mit Drainagen [12] oder chirurgische Narben und Hautfalten, die Mikroorganismen beherbergen [5]. Bei unserer Patientin wurden jedoch keine derartigen Risikofaktoren festgestellt.…”

Section: Diskussionunclassified