A case of primary biliary cirrhosis associated with hepatocellular carcinoma and systemic lupus erythematodes

Ishiguro, Haruya; Kimura, Takazumi; Nikami, Toshiki; Yoshizawa, Kai; Abé, Hiroshi; Sutou, Satoshi; Aizawa, Yoshifusa; Sakata, Akihiko; Tajiri, Hisao

doi:10.2957/kanzo.52.679

Cited by 3 publications

(16 citation statements)

References 15 publications

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“…Systemic lupus erythematosus (SLE) is an autoimmune disease that often coexists with other collagen disorders, such as rheumatoid arthritis (RA) and Sjögren's syndrome (SjS) [1,2]; however, cases of concomitant SLE and primary biliary cirrhosis (PBC) are rare [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. SLE is a multisystem autoimmune disease that results from a combination of genetic, environmental, and hormonal factors.…”

Section: Introductionmentioning

confidence: 99%

“…SLE is a multisystem autoimmune disease that results from a combination of genetic, environmental, and hormonal factors. On the other hand, PBC is considered an autoimmune disease characterized by chronic progressive cholestasis with destruction of the intrahepatic small bile ducts, particularly the interlobular bile ducts [19,20]. Chronic nonsuppurative destructive cholangitis and granuloma formation are well-known histological findings of PBC.…”

Section: Introductionmentioning

confidence: 99%

“…Prognosis of PBC is often dependent on the development of portal hypertension or cirrhosis, indicating liver failure. Although the incidence of concomitant hepatocellular carcinoma (HCC) with PBC is relatively rare, several studies have reported incidence rates of <1.6% [19,21,22]. Harada et al [20] reported that incidence of HCC in PBC patients has been increasing in recent decades in Japan.…”

Section: Introductionmentioning

confidence: 99%

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Coexistence of Systemic Lupus Erythematosus and Primary Biliary Cirrhosis

Shizuma¹

2014

J Clin Cell Immunol

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Although autoimmune diseases often coexist, cases of concomitant systemic lupus erythematosus (SLE) and primary biliary cirrhosis (PBC) are rare. In this paper, 20 cases of concomitant SLE and PBC in the English and Japanese literature were reviewed and summarized. In concomitant cases of SLE and PBC, PBC was diagnosed first in 68.4% (13/19) of the cases and SLE occurred first in 31.6% (6/19) of the cases, although one case was suspected to have simultaneous onset. There may be no correlation between SLE activity and PBC development. In 20 reported cases of concomitant SLE and PBC, two elderly patients died because of liver failure as a result of worsening PBC, and hepatocellular carcinoma was detected in only one elderly patient.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Coexistence of Systemic Lupus Erythematosus and Primary Biliary Cirrhosis

Shizuma¹

2014

J Clin Cell Immunol

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“…Although the incidences of Hepatocellular Carcinoma (HCC) with concomitant PBC are relatively rare [30,41], Ishiguro et al [30] have reported the case of an 81-year-old Japanese woman who developed SLE and HCC approximately one year after the diagnosis of PBC. To the best of our knowledge, this is the only case report of PBC with concomitant SLE that was concurrent with the development of HCC.…”

Section: Pbc In Patients With Slementioning

confidence: 99%

“…It is described as an organ-specific disturbance characterized by chronic progressive cholestasis that destroys the intrahepatic small bile ducts, particularly the interlobular bile ducts [30][31][32][33][34]. Pertaining to the histopathological aspects of PBC, the findings in florid bile duct lesions such as chronic, nonsuppurative destructive cholangitis and epithelioid granuloma formation are established and useful for diagnosing PBC [34].…”

Section: Pbc In Patients With Slementioning

confidence: 99%

Liver Complications Associated with Systemic Lupus Erythematosus

Shizuma

2015

Rheumatology (Sunnyvale)

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Although liver dysfunction is not considered the main organ pathology or prognostic factor in patients with Systemic Lupus Erythematosus (SLE), it is not uncommon during the course of SLE. Liver complications in patients with SLE may be caused by lupus hepatitis (SLE-related hepatitis); autoimmune liver diseases, such as Autoimmune Hepatitis (AIH) and Primary Biliary Cirrhosis (PBC); viral hepatitis; and drug-induced liver injury. Here, liver complications in patients with SLE are reviewed.

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Clinical Characteristics of Concomitant Systemic Lupus Erythematosus and Primary Biliary Cirrhosis: A Literature Review

Shizuma

2015

Journal of Immunology Research

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Although autoimmune diseases often coexist, concomitant cases of systemic lupus erythematosus (SLE) and primary biliary cirrhosis (PBC) are uncommon. In this review paper, 34 cases of SLE with concomitant PBC found in English and Japanese scientific literature and Japanese proceedings were reviewed and summarized, including cases with liver dysfunction complicated by SLE. Of the 34 reported concomitant cases of SLE and PBC, 97.1% (33/34) were females, and PBC was diagnosed initially in 69.0% (20/29), except for five cases in which both SLE and PBC were simultaneously diagnosed. Sjögren's syndrome was the most common autoimmune disease complicating concomitant SLE and PBC (23.5%, 8/34). Five deaths have been reported: two elderly patients died of liver failure because of the worsening of PBC, and another two patients died from pulmonary infection associated with SLE pharmacotherapy. It is uncertain whether concomitant cases occur by chance or share a common immunological or genetic basis.

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A case of primary biliary cirrhosis associated with hepatocellular carcinoma and systemic lupus erythematodes

Cited by 3 publications

References 15 publications

Coexistence of Systemic Lupus Erythematosus and Primary Biliary Cirrhosis

Coexistence of Systemic Lupus Erythematosus and Primary Biliary Cirrhosis

Liver Complications Associated with Systemic Lupus Erythematosus

Clinical Characteristics of Concomitant Systemic Lupus Erythematosus and Primary Biliary Cirrhosis: A Literature Review

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