A Case of Primary Aldosteronism with Chronic Renal Failure Undergoing Hemodialysis Treatment.

Matsuda, Katsuhiro; Shimamoto, Kazuaki; Ura, Nobuyuki; Ogata, Hitoko; Shizukuda, Yukitaka; Iwakura, Masahiro; Nozawa, Akihiko; Kikuchi, Kenjiro; Ito, Osamu

doi:10.1507/endocrj1954.36.681

Cited by 12 publications

(7 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PRA remains in the normal range in 8.8-18.5% of patients with primary aldosteronism [2,11]. In previous reports (table 1), low PRA was noted in only 3 cases [16,19,22]. Iyori et al [16] suggested that renin secretion might be affected by the balance of two factors, i.e.…”

Section: Discussionmentioning

confidence: 92%

Aldosterone-Producing Adrenocortical Adenoma Complicated by Chronic Renal Failure

Itoh¹,

Sasaoka

Takao

et al. 1998

Am J Nephrol

View full text Add to dashboard Cite

A 61-year-old Japanese woman was hospitalized because of general malaise. The patient demonstrated hypertension, hypokalemia and chronic renal failure (CRF). Plasma aldosterone concentration and urinary excretion of aldosterone were elevated. Abdominal computed tomographic scan revealed right adrenal tumor and multiple cysts in both kidneys. Adrenal scintigram using ¹³¹I-adosterol disclosed uptake of the isotope in the area corresponding to the adrenal tumor. Plasma aldosterone concentration and renin activity (PRA) in an upright posture and daily variations in adrenocorticotropic hormone, cortisol, aldosterone levels and PRA were compatible with aldosterone-producing adrenocortical adenoma. After administration of spironolactone and manidipine hydrochloride, a calcium antagonist, general malaise disappeared, and blood pressure and serum potassium level returned to the normal range without adrenalectomy. Although adrenalectomy is known to be effective for the treatment of aldosterone-producing adrenocortical adenoma, several papers reporting cases of aldosterone-producing adrenocortical adenoma with CRF indicated that surgical therapy was not always optimal in terms of postoperative conditions. Taken together, the conservative therapy may be one of the choices considering the prognoses of hypertension and renal dysfunction in patients with aldosterone-producing adrenocortical adenoma with CRF.

show abstract

Section: Discussionmentioning

confidence: 92%

Aldosterone-Producing Adrenocortical Adenoma Complicated by Chronic Renal Failure

Itoh¹,

Sasaoka

Takao

et al. 1998

Am J Nephrol

View full text Add to dashboard Cite

show abstract

“…Therefore, in primary aldosteronism with chronic renal failure, the serum potassium level seems to be determined by the balance of the augmentation and the suppression of potassium excretion by excess aldosterone and renal failure, respectively3, 5).…”

Section: Discussionmentioning

confidence: 99%

“…In case of primary aldosteronism with chronic renal failure, there is difficult to be diagnosed because hypertension is frequently associated with chronic renal failure. A few cases with primary aldosteronism accompanying chronic renal failure or end stage renal disease have been reported3-5). Two cases of primary aldosteronism with chronic renal failure6, 7) and one case with autosomal dominant polycystic kidney disease8) have been reported in Korea.…”

Section: Introductionmentioning

confidence: 99%

A Case of Primary Aldosteronism with End Stage Renal Disease

Park

Kim

et al. 2006

Electrolyte Blood Press

View full text Add to dashboard Cite

A 52-year-old woman was referred to our hospital due to chronic renal failure with a 10-year history of hypertension. We found polycystic kidney disease, pulmonary tuberculosis and an aldosterone-producing adrenocortical mass. At this time, her serum potassium level and blood pressure were within the normal range. She refused hemodialysis and then was hospitalized because of uremic encephalopathy. On admission, her serum potassium level was normal without treatment and plasma aldosterone concentration highly elevated. She received hemodialysis, and thereafter hypokalemia developed. We then administered spironolactone, whereupon serum potassium level returned to the normal range. In this case, we thought that normokalemia was balanced hypokalemia of primary aldosteronism with hyperkalemia of chronic renal failure, and that hypokalemia developed after hemodialysis was due to an imbalanced primary aldosteronism with end stage renal disease.

show abstract

“…Spironolactone is a nonselective MR antagonist with an incidence of gynecomastia of approximately 7 % for doses at 50 mg/day and of more than 50 % for doses higher than 150 mg/day. Matsuda and colleagues [133] found that fecal potassium excretion in an anuric patient with PA and hypokalemia decreased while serum potassium increased after administration of spironolactone 50 mg/day. Eplerenone is a selective MR antagonist with 60 % of the potency of spironolactone and a shorter half-life but similar antihypertensive efficacy [134].…”

Section: Adrenalectomymentioning

confidence: 98%

Chronic Kidney Disease and Hypertension

Weir¹,

Lerma²

2015

View full text Add to dashboard Cite

A Case of Primary Aldosteronism with Chronic Renal Failure Undergoing Hemodialysis Treatment.

Abstract: A 56-year-old man with primary aldosteronism and chronic renal failure undergoing hemodialysis is described.

Cited by 12 publications

References 5 publications

Aldosterone-Producing Adrenocortical Adenoma Complicated by Chronic Renal Failure

Aldosterone-Producing Adrenocortical Adenoma Complicated by Chronic Renal Failure

A Case of Primary Aldosteronism with End Stage Renal Disease

Chronic Kidney Disease and Hypertension

Contact Info

Product

Resources

About