A Case of Primary Addiction to Meprobamate

Jc, Little

doi:10.1136/bmj.2.5360.794

Cited by 5 publications

(2 citation statements)

References 6 publications

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“…She was treated with phenytoin, carbamazepine and clonazepam. This approach differs from the historical literature, where meprobamate withdrawal was managed through slow reduction (sometimes with additional chlorpromazine) 13. In a recent case report by Demir et al ,14 a patient was withdrawn from phenprobamate (which is metabolised to meprobamate) with diazepam, plus, for an unspecified time, both paroxetine and quetiapine.…”

Section: Discussionmentioning

confidence: 99%

Something old, something new: a successful case of meprobamate withdrawal

2016

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Meprobamate, a benzodiazepine-like drug, was commonly prescribed for anxiety in the 1960s and 1970s, but fell out of favour, at least in part, due to the risk of dependence, for which there is little published evidence to guide clinical management. We discuss a 70-year-old man with a 45-year history of meprobamate dependency and multiple failed previous withdrawal attempts who was successfully withdrawn from meprobamate using diazepam during a 2-week inpatient stay on a specialist Addictions ward. An appropriate diazepam dose was established using the Clinical Institute Withdrawal Assessment scale for benzodiazepines (CIWA-B). This dose was then slowly reduced over 12 days. Multidisciplinary input, especially psychological therapy tackling his underlying anxiety disorder during his admission, was thought to be particularly helpful.

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Section: Discussionmentioning

confidence: 99%

Something old, something new: a successful case of meprobamate withdrawal

2016

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“…Meprobamate is the other drug in wide use in this type of patient. Controlled trials suggest that its antianxiety effects are slight, 3' 4 and some cases of addiction have been reported.5 6 Chlordiazepoxide This drug is chemically described as 7-chloro-2-methylamino-5-phenyl-3H-benzo-1,4-diazepine-4-oxide hydrochloride. It was the first of the benzodiazepines to be introduced.…”

Section: Clinical Usementioning

confidence: 99%