A Case of Primary Accessory Breast Cancer in a Male

Nagaoka, Hiroshi; Takahashi, Takefumi; Sugitani, Kazuhiro; Nakagami, Katsunao; Kim, Yuji; Yoshida, Yutaka; Ooki, Uki; Endo, Keiichi; Kamatsuda, Masaki; Shimokata, Naomi; Takahashi, Kozue; Oota, Yasunori

doi:10.2974/kmj.64.165

Cited by 2 publications

(2 citation statements)

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“…Accessory breast carcinoma in males is rare [1][2][3]. In addition to Maki et al's compilation of Japanese reports from 1996 to 2013 [4], we performed a journal search using "Men/accessory Breast Cancer" as keywords and found that from January 2014 to June 2020, only 26 cases of accessory breast cancer in males were reported in Japan.…”

Section: Discussionmentioning

confidence: 99%

“…Breast carcinoma in males accounts for just 0.6% of all malignant breast neoplasm cases in Japan [ 1 ]. The total incidence rate of accessory breast carcinoma is 0.2–0.6% [ 2 ], and males account for only 2.4–5.3% of accessory breast carcinoma cases, making it rare [ 3 ]. In cases of male breast cancer, it is important to consider the potential for hereditary breast cancer, including cancers associated with BRCA gene mutation.…”

Section: Introductionmentioning

confidence: 99%

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A male with primary accessory breast carcinoma in an axilla is strongly suspected of having hereditary breast cancer

et al. 2021

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We herein report on a male with primary accessory breast cancer in an axilla. A 75-year-old man first noticed a subcutaneous nodule about 2 cm in diameter in the area of his right axilla. The patient underwent extirpation of the mass in a public hospital. Histological examination revealed invasive breast carcinoma of no special type associated with mucinous carcinoma, invasive micropapillary carcinoma and intraductal components. Immunohistochemical analysis showed that the tumor cells were positive for Gross cystic disease fluid protein (GCDFP)-15, mammaglobin and GATA3. Staining for estrogen receptor (ER) and progesterone receptor (PR) was positive, and human epidermal growth factor receptor 2 (HER2) was negative. The Ki67 labeling index (LI) was 33.6%. Imaging revealed no evidence of a primary tumor in any other organ or in the bilateral mammary gland. We performed radical resection of the right axilla, including the scar, and axillary lymph node dissection. The final pathological examination of the surgical specimen showed normal mammary gland tissue that was not connected to the proper mammary gland, and no residual cancer or metastatic lymph nodes. Based on our clinical and pathological findings, this tumor was diagnosed as breast cancer originating from the accessory mammary gland in the right axilla. After surgery, tamoxifen was administered as adjuvant therapy. Since the surgery, 2 years ago, there has been no evidence of recurrence. Hereditary Breast and Ovarian Cancer syndrome was suspected in this case because the patient was a male with breast cancer, and he had two first-degree relatives with breast cancer. This patient had no BRCA mutations on genetic testing. Nonetheless, in cases of male breast cancer, it is necessary to obtain genetic information due to the possibility of hereditary breast cancer, including cancers associated with BRCA gene mutation.

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Section: Discussionmentioning

confidence: 99%