A Case of Pregnancy Complicated with Type 1 Hereditary Angioedema (HAE 1)

Abstract

Hereditary angioedema (HAE) is an inherited autosomal dominant trait and symptoms of HAE include sudden onset of edema in various organs, such as subcutaneous edema, laryngeal edema and gastrointestinal tracts mucosa. We have experienced a case of a pregnant woman diagnosed with HAE and successfully managed her pregnancy. The patient was 37 years old, gravida 1, primiparous. She had experienced two attacks of angioedema during pregnancy but her delivery course was not affected by her HAE. The frequency of attacks during pregnancy had decreased compared with before and after pregnancy. Treatment using human C1-inactivator concentrate was as effective for attack suppression during pregnancy as it had been in her non-pregnant state.

Hereditary angioedema caused by C1-esterase inhibitor deficiency: a case report with literature-based analysis

“…[3][4][5] Some studies have demonstrated increase in the attack rates with the subsequent pregnancies. 6,7 Different effects of HAE on pregnancy and postpartum period have been noted. Some patients have flare-ups while some experience improvement of symptoms.…”