A Case of Precocious Puberty in a Female

McGeorge, Murray; Connor, Dawn

doi:10.1136/adc.36.188.439

Cited by 7 publications

(6 citation statements)

References 18 publications

(17 reference statements)

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“…Previous observations (McGeorge and Connor, 1961) confirmed that the development ofthe dentition was relatively unaffected, despite the advanced skeletal maturation associated with idiopathic sexual precocity in this patient.…”

Section: Dental Developmentsupporting

confidence: 84%

“…Although clinical details of this case have already been reported (McGeorge and Connor, 1961), the more important features are summarized here as background to additional data now presented.…”

Section: Outline Of the Casementioning

confidence: 94%

“…One of the most striking features was the pattern of skeletal development. At 20 months the bone age was assessed as 4-5 years and at 27 months as 10 years-an increment equivalent to 5-5 years of normal growth in a period of seven months (McGeorge and Connor, 1961). During the next four years the rate of skeletal maturation approximated to normal but with the bone age consistently about 11 years ahead of the chronological age.…”

Section: Skeletal Developmentmentioning

confidence: 99%

“…The ease to be reported illustrates an extreme departure from the norm of pubertal development and offers an opportunity to examine this condition in relation to other aspects of development. In particular, psycho-social aspects of a case of grossly accelerated puberty first reported by McGeorge and Connor (1961) will be further considered.…”

Section: Introductionmentioning

confidence: 99%

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Psychological Aspects of Accelerated Pubertal Development

Connor

McGeorge

1965

Child Psychology Psychiatry

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Section: Dental Developmentsupporting

confidence: 84%

Section: Outline Of the Casementioning

confidence: 94%

Section: Skeletal Developmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Psychological Aspects of Accelerated Pubertal Development

Connor

McGeorge

1965

Child Psychology Psychiatry

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“…It also allows one to alter the usual chronological sequence of events and thus bring about distortions of form, but one can never escape entirely from the effects of age. An abnormal hormone balance, as one gets in cases of precocious puberty (McGeorge & Connor 1961;Ferrier, Shepard & Smith 1961), may break through the integration in a totally different way and make the intake of food and the size of the animal conform with its demands, but with this we are not directly concerned. The present experiments bring out rela tionships, only some of which oan be matched from the literature, and it is these we propose to discuss.…”

Section: Interpretationsmentioning

confidence: 99%

Nutrition and growth

McCance

Widdowson

1962

Proc. R. Soc. Lond. B.

123

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Long before the present century there was general appreciation of the fact that good growth called for good food and plenty of it. Hopkins’s isolation of tryptophane and his pre-occupation with vitamins always led him to emphasize that something more was required and that satisfactory growth was only possible on a ‘balanced’ diet. By this he meant adequate in all respects—proteins in general, amino-acids in particular, calories, vitamins and minerals (Hopkins 1920, 1925). Since that time everything has gone to vindicate Hopkins’s foresight, but a great many further discoveries have been made about the bearing of nutrition on growth. These have all emphasized the co-ordinated nature of the process, and it is with some of these discoveries that this paper will be concerned. The nutrition of children in this country has been progressively altered in the last 40 years by the provision of cheap milk, school meals and a rising standard of living. At each chronological age, moreover, down to the age of 5, the heights and weights of children have been shown to have risen progressively in a number of countries over the last 50 years and to be still rising (Tanner 1955; Acheson i960). The height of adults has probably risen too (Boyne & Leitch 1954; Boyne i960). With this increase in children’s size has gone earlier maturity and all that this involves. These observations on man recall those which Osborne & Mendel (1926) reported from their rat colony over a period of 15 years. The charges described by them were certainly nutritional in origin and considered to be beneficial in every way. McCay, Maynard, Sperling & Barnes (1939) and others, however (Ross 1959; Berg & Simms 1960), have shown in growing rats that prolonged undernutrition and delayed development after weaning may greatly increase the normal life span, and the subject was reviewed by Silberberg & Silberberg (1955) and Comfort (i960). McCance (1953) suggested that the rehabilitation of undernourished German children after the war might be shortening their expectation of life, and it has even been proposed that a progressive curtailment in the expectation of life may be accompanying the secular trends in children’s heights and weights (Sinclair 1955). It is by no means certain, however, that the secular trends are wholly nutritional in origin. They may be due to out-breeding (Tanner 1955) or to other causes (Editorial 1961).

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The bearing of the plane of nutrition on growth and endocrine development

McCance¹,

Widdowson²

1962

Protein Metabolism

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A Case of Precocious Puberty in a Female

Cited by 7 publications

References 18 publications

Psychological Aspects of Accelerated Pubertal Development

Psychological Aspects of Accelerated Pubertal Development

Nutrition and growth

The bearing of the plane of nutrition on growth and endocrine development

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