A Case of Postpartum Takotsubo (Stress) Cardiomyopathy

Takotsubo cardiomyopathy (TCM) is most common in postmenopausal women aged ≥ 50 years but also affects pregnant individuals. However, there are no national estimates on the prevalence, timing of occurrence, correlates, and outcomes of Pregnancy-associated TCM. Using the Nationwide Inpatient Sample (NIS: 2016-2020), we describe rates of pregnancy-associated TCM hospitalizations among 13 - 49 years old pregnant individuals in the United States by selected demographic, behavioral, hospital, and clinical characteristics. Joinpoint regression was used to describe the Annual Average Percent Change of pregnancy-associated TCM hospitalizations. Survey logistic regression was used to measure the association of pregnancy-associated TCM hospitalizations with maternal outcomes. Of the 19,754,535 pregnancy-associated hospitalizations, 590 were TCM-associated. The overall trend in pregnancy-associated TCM hospitalizations remained stable during the study period. The majority of TCM occurred during the postpartum, followed by antepartum and delivery-associated hospitalizations. Compared to pregnancy hospitalizations without TCM, those with TCM were more likely to be over the age of 35 years and use tobacco and opioids. Comorbidities during TCM-associated pregnancy hospitalizations included heart failure, coronary artery disease, hemorrhagic stroke, and hypertension. After controlling for potential confounders, the odds of pregnancy-associated TCM hospitalizations were 98.7 times (aOR 98.66, 95% CI: 31.23, 311.64) and 14.7 times (aOR 14.75, 95% CI: 9.99, 21.76) higher for experiencing in-hospital mortality and a prolonged hospital stay, respectively, than those without TCM. Although rare, pregnancy-associated TCM hospitalization is more likely to occur during the postpartum period and is associated with in-hospital mortality and prolonged hospital stay.

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Pregnancy-associated takotsubo cardiomyopathy hospitalizations in the United States

Mogos

Ahn

Muchira

et al. 2023

American Journal of Physiology-Heart and Circulatory Physiology

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A Case of Postpartum Takotsubo (Stress) Cardiomyopathy

Abstract: Takotsubo (stress) cardiomyopathy (TCM) is usually triggered by psychological and/or physical stress. Most often, it is seen in postmenopausal women. Cases of TCM related to pregnancy are rare. We present a unique case of a 35-year-old, two-day postpartum female who was diagnosed with TCM.

Cited by 1 publication

References 11 publications

Pregnancy-associated takotsubo cardiomyopathy hospitalizations in the United States

Pregnancy-associated takotsubo cardiomyopathy hospitalizations in the United States

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