A Case of Pork-cat Syndrome That Developed as Food-dependent Exercise-induced Anaphylaxis

Shiratsuki, Rie; Chinuki, Yuko; Fukushiro, Shinji; Morita, Eishin

doi:10.2340/00015555-3584

Cited by 5 publications

(3 citation statements)

References 4 publications

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“…Frequent contact with cats may induce sensitization to Fel d2 of cat, which can cause a cross-reactivity to pork and beef. 31 A key aspect of our study was the association between positive beef-specific IgE and male sex (p < 0.001, n = 300; Table 6), although no association was found between positive BTG-specific IgE test and sex (p = 0.082, n = 300; Table 5). Currently, there is no evidence of an association of α-Gal syndrome with difference in sex; 22,24,32,33 however, Orhan et al 34 reported 12 patients with beef allergy and a 3:9 sex ratio of female to male.…”

Section: Discussionmentioning

confidence: 74%

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Cohort study of subclinical sensitization against galactose‐α‐1,3‐galactose in Japan: Prevalence and regional variations

Nakagawa

Chinuki

Ogino

et al. 2022

The Journal of Dermatology

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Sensitization to galactose‐α‐1,3‐galactose (α‐Gal) leads to the development of α‐Gal syndrome, which includes red meat allergy and cetuximab‐induced anaphylaxis. Since tick bites represent the main cause of α‐Gal sensitization, it was speculated that sensitization to α‐Gal occurs throughout Japan. However, few cohort studies have investigated α‐Gal sensitization in Japan. Therefore, we aimed to elucidate the subclinical sensitization rate to α‐Gal in Japan. Sera were obtained from 300 participants without food or cetuximab allergy at Shimane University Hospital (Shimane prefecture), Tokyo Medical and Dental University Hospital (Tokyo metropolis), and Tohoku University Hospital (Miyagi prefecture). ImmunoCAP‐bovine thyroglobulin (BTG), ImmunoCAP‐beef, and IgE immunoblotting with cetuximab were performed to detect α‐Gal‐specific IgE. Clinical information was collected from participants using a questionnaire. The overall positivity rate of ImmunoCAP‐BTG was 4.0% without significant inter‐institute differences, whereas that for ImmunoCAP‐beef was 9.7% with a significant inter‐institute difference. Tokyo Medical and Dental University Hospital (19.0%) had the highest positivity rate. The positivity rate based on cetuximab IgE immunoblotting was 2.7%, without any significant inter‐institute differences. The overall positivity rate for both ImmunoCAP‐BTG and cetuximab immunoblotting was 2.0%, with a significant inter‐institute difference; 5.0% of Shimane University Hospital was the highest. Two cases showed sensitization against the non‐α‐Gal epitope of cetuximab. The overall positivity rate for both ImmunoCAP‐beef and cetuximab immunoblotting was 1.3%, without significant inter‐institute differences. Male sex was associated with positive beef‐specific IgE. The prevalence of subclinical sensitization to α‐Gal is estimated at 2.0%–4.0% in Japan and may be higher in rural areas, supporting an association between tick bites and α‐Gal sensitization. In contrast, the prevalence of subclinical sensitization to beef is 9.7% in Japan and is highest in Tokyo Metropolis, suggesting the presence of another IgE‐binding epitope apart from α‐Gal and another sensitization route in the sensitization to beef IgE.

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Section: Discussionmentioning

confidence: 74%

“…In Tokyo, where there are fewer grounds than in rural areas, it is estimated that the ratio of keeping pets indoors is high. Frequent contact with cats may induce sensitization to Fel d2 of cat, which can cause a cross‐reactivity to pork and beef 31 …”

Section: Discussionmentioning

confidence: 99%

Cohort study of subclinical sensitization against galactose‐α‐1,3‐galactose in Japan: Prevalence and regional variations

Nakagawa

Chinuki

Ogino

et al. 2022

The Journal of Dermatology

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“…Cat-pork syndrome is more common in adults, but some pediatric cases were reported [ 61 , 62 ], even after consuming beef intestines [ 63 ]. Additionally, a case of FDEIA (Food-Dependent Exercise-Induced Anaphylaxis) was described in a 13-year-old boy that developed urticaria and dyspnoea during intense exercise after ingestion of pork [ 64 ].…”

Section: Ingestionmentioning

confidence: 99%

Hidden and Rare Food Allergens in Pediatric Age

et al. 2023

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In food allergy management, the avoidance of the allergen that caused the reaction plays a fundamental role. Nevertheless, that can be thwarted in case of accidental exposure to a rare or hidden allergen, causing the adoption of a monotonous diet and a consequent reduction in the quality of life of the patient and their family. The identification of a rare and hidden allergen is an important diagnostic challenge, taking into account that a significant proportion of all food reactions is in reality due to them. The aim of the present review is to provide the pediatric allergist an overview of the possible sources of rare and hidden food allergens, taking into consideration the routes of exposure to these potential allergens with the main examples published in the scientific literature and the distinction between types of direct or cross-contamination. The identification of the allergen responsible for the reaction and the provision of a dietary advice customized for the specific individual’s dietary habits is essential to improve quality of life of the familiar nucleus and to reduce the risk of further allergic reactions.

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