A case of platelet GPIIb/IIIa abnormality which shows lag time in ADP-induced aggregation.

Abstract

A 38-year-old woman was admitted to our hospital on Nov. '85 because of mild bleeding tendency. There was past history of malignant lynphoma of the stomach at age 34. Then she had gastrectomy and splenectomy with subsequent X-ray therapy.Coagulation tests on admission revealed ; platelet count 259,000/pl; bleeding time (Duke), 8.5min.; whole blood clotting time, prothrombin time, partial thromboplastin time were normal. There was the abnormality of platelet function to aggregate in response to ADP, epinephrine and collagen, whereas ristocetin-induced agglutination was normal (Fig.