A case of pituitary abscess presenting without a source of infection or prior pituitary pathology

Adams, Derick; Kern, Philip A.

doi:10.1530/edm-16-0046

Cited by 5 publications

(2 citation statements)

References 10 publications

(22 reference statements)

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“…Within adults, S. capitis infection has resulted in a number of different clinical presentations. These include the following: Native valve endocarditis [ 48 , 49 , 50 , 51 , 52 ]; Prosthetic valve endocarditis [ 53 , 54 , 55 , 56 , 57 , 58 ]; Osteomyelitis [ 59 , 60 , 61 , 62 ]; Polymicrobial infections [ 63 , 64 , 65 , 66 ]; Surgical implant infections [ 67 , 68 , 69 , 70 , 71 ]; …”

Section: Clinical Presentations and Managementmentioning

confidence: 99%

Staphylococcus capitis: Review of Its Role in Infections and Outbreaks

et al. 2023

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In June 2021, a national incident team was formed due to an increased detection of Staphylococcus capitis in samples from hospitalised infants. Staphylococcus capitis has been known to cause outbreaks in neonatal units across the globe, but the extent of the UK spread was unclear. A literature review was undertaken to support case identification, clinical management and environmental infection control. A literature search was undertaken on multiple databases from inception to 24 May 2021, using keywords such as “Staphylococcus capitis”, “NRCS-A”, “S. capitis”, “neonate”, “newborn” and “neonatal intensive care unit” (NICU). After screening, 223 articles of relevance were included. Results show incidences of S. capitis outbreaks have frequently been associated with the outbreak clone (NRCS-A) and environmental sources. The NRCS-A harbours a multidrug resistance profile that includes resistance to beta-lactam antibiotics and aminoglycosides, with several papers noting resistance or heteroresistance to vancomycin. The NRCS-A clone also harbours a novel SCCmec-SCCcad/ars/cop composite island and increased vancomycin resistance. The S. capitis NRCS-A clone has been detected for decades, but the reasons for the potentially increased frequency are unclear, as are the most effective interventions to manage outbreaks associated with this clone. This supports the need for improvements in environmental control and decontamination strategies to prevent transmission.

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Section: Clinical Presentations and Managementmentioning

confidence: 99%

Staphylococcus capitis: Review of Its Role in Infections and Outbreaks

et al. 2023

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“…The direct spread or hematogenous dissemination of sphenoid sinusitis may play a role in the pathogenesis, which is the mechanism of abscess formation most commonly reported [27] . Kroppenstedt reported that PA formation is closely associated with blood circulation disorders and tumor necrosis resulting from systemic or regional immune dysfunction [28] .…”

Section: Pathogenesismentioning

confidence: 99%

Pituitary abscess: A descriptive analysis of a series of 19 patients: a multi-center experience

Qin¹,

Shi

et al. 2023

Preprint

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Object: The study aims to investigate the intractable pituitary abscess (PA) diagnosis and assess the significance of combined intraoperative surgery with postoperative antibiotic treatment. Method: We retrospectively analyzed 19 pituitary abscess patients confirmed by histopathology, all consecutive patients who underwent transsphenoidal surgery (TSS) as pituitary adenomas after accepting comprehensive preoperative inspections, including routine tests, endocrine assay, and imaging examination. Result: Other sellar lesions were misdiagnosed prior to surgery. The favorable prognosis was largely due to surgical and active postoperative antibiotic therapy. Conclusion: Due to the lack of clarity in preoperative diagnosis, typical intraoperative findings and effective antibiotics are more indicative of the correct diagnosis than other tests. When it comes to therapy, optimal surgical and postoperative active antibiotic treatment benefits the PA dilemma.

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Staphylococcus capitis : insights into epidemiology, virulence, and antimicrobial resistance of a clinically relevant bacterial species

Crepin,

Chavignon,

Verhoeven

et al. 2024

Clin Microbiol Rev

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SUMMARY Staphylococcus capitis is divided into two subspecies, S. capitis subsp. ureolyticus (renamed urealyticus in 1992; ATCC 49326) and S. capitis subsp. capitis (ATCC 27840), and fits with the archetype of clinically relevant coagulase-negative staphylococci (CoNS). S. capitis is a commensal bacterium of the skin in humans, which must be considered an opportunistic pathogen of interest particularly as soon as it is identified in a clinically relevant specimen from an immunocompromised patient. Several studies have highlighted the potential determinants underlying S. capitis pathogenicity, resistance profiles, and virulence factors. In addition, mobile genetic element acquisitions and mutations contribute to S. capitis genome adaptation to its environment. Over the past decades, antibiotic resistance has been identified for S. capitis in almost all the families of the currently available antibiotics and is related to the emergence of multidrug-resistant clones of high clinical significance. The present review summarizes the current knowledge concerning the taxonomic position of S. capitis among staphylococci, the involvement of this species in human colonization and diseases, the virulence factors supporting its pathogenicity, and the phenotypic and genomic antimicrobial resistance profiles of this species.

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A case of pituitary abscess presenting without a source of infection or prior pituitary pathology

Cited by 5 publications

References 10 publications

Staphylococcus capitis: Review of Its Role in Infections and Outbreaks

Staphylococcus capitis: Review of Its Role in Infections and Outbreaks

Pituitary abscess: A descriptive analysis of a series of 19 patients: a multi-center experience

Staphylococcus capitis : insights into epidemiology, virulence, and antimicrobial resistance of a clinically relevant bacterial species

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