2001
DOI: 10.1007/s004040000167
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A case of persistent endometriosis after total hysterectomy with both salpingo-oophorectomy managed by radiation therapy

Abstract: Persistent endometriosis after total hysterectomy and both salpingo-oophorectomy (TH with BSO) is a rare condition and the etiology is uncertain. The exact incidence of persistent endometriosis after definitive surgery is not known. In addition, the treatment of persistent endometriosis after complete surgical excision is controversial. We report a case of persistent endometriosis with vaginal and sigmoid-colonic invasion after TH with BSO. The lesions were not responsive to hormonal therapy. The patient was m… Show more

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Cited by 14 publications
(11 citation statements)
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“…7B). BSO, a relative specific inhibitor of glutathione biosynthesis, is frequently used to manipulate the level of glutathione both in vitro and in vivo (Kim et al, 2001;Mohamed et al, 2000). A large amount of evidence suggests that multiple molecular mechanisms contribute to the GSH protective action.…”
Section: Discussionmentioning
confidence: 99%
“…7B). BSO, a relative specific inhibitor of glutathione biosynthesis, is frequently used to manipulate the level of glutathione both in vitro and in vivo (Kim et al, 2001;Mohamed et al, 2000). A large amount of evidence suggests that multiple molecular mechanisms contribute to the GSH protective action.…”
Section: Discussionmentioning
confidence: 99%
“…A previous study estimated that the 50% lethal dose (LD 50 ) for human oocytes was 4Gy or less [11]. Several studies reported the ability of radiotherapy for ablating remnant ovarian tissue in recurrent or refractory endometriosis, based on the limited tolerance of human oocytes to radiation damage [12-14]. These studies reported that menopause was induced at a dose of 15 to 30Gy radiation.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, there is some reported benefit of radiotherapy in refractory endometriosis. 17 Hence, in our case it may be argued that the radiotherapy might have assisted in "thawing" the frozen pelvis to render it operable.…”
Section: Discussionmentioning
confidence: 95%