A Case of Peripheral Polyneuropathy Induced by Occupational 2,5-hexanedione Exposure

Cho, Seong‐Yong; Jang, Yong Seok; Choi, Eun Kyung; Kim, Jin Seok; Yu, Jay Young; Woo, Kuck Hyun; Choi, Tae Seong

doi:10.35371/kjoem.2007.19.1.73

Cited by 5 publications

(4 citation statements)

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“…N-hexane-induced peripheral neuropathy has been known to produce sensorimotor neuropathy with significant motor weakness; however, recent cases of n-hexane-induced peripheral neuropathy predominantly involved sensory disturbances, probably due to low levels of exposure 7,65. In addition, 2,5-hexanedione, a metabolite of n-hexane, caused toxic peripheral neuropathy, similar to recent mild cases involving n-hexane 7,65,66…”

Section: Clinical Manifestations and Toxicological Implications Of Masupporting

confidence: 62%

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Occupational Neurologic Disorders in Korea

et al. 2010

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This article presents a schematic review of the clinical manifestations of occupational neurologic disorders in Korea and discusses the toxicologic implications of these conditions. Vascular encephalopathy, parkinsonism, chronic toxic encephalopathy, cerebellar dysfunction, peripheral neuropathy, and neurodegenerative diseases are common presentations of occupational neurotoxic syndromes in Korea. Few neurotoxins cause patients to present with pathognomic neurologic syndrome. Detailed neurologic examinations and categorization of the clinical manifestations of neurologic disorders will improve the clinical management of occupational neurologic diseases. Physicians must be aware of the typical signs and symptoms of possible exposure to neurotoxins, and they should also pay attention to less-typical, rather-vague symptoms and signs in workers because the toxicologic characteristics of occupational neurologic diseases in Korea have changed from typical patterns to less-typical or equivocal patterns. This shift is likely to be due to several years of low-dose exposure, perhaps combined with the effects of aging, and new types of possibly toxicant-related neurodegenerative diseases. Close collaboration between neurologists and occupational physicians is needed to determine whether neurologic disorders are work-related.

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Section: Clinical Manifestations and Toxicological Implications Of Masupporting

confidence: 62%

“… 7 , 65 In addition, 2,5-hexanedione, a metabolite of n-hexane, caused toxic peripheral neuropathy, similar to recent mild cases involving n-hexane. 7 , 65 , 66 …”

Section: Clinical Manifestations and Toxicological Implications Of Mamentioning

confidence: 99%

Occupational Neurologic Disorders in Korea

et al. 2010

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“…The most commonly reported neurological disorder of the PNS was peripheral neuritis ( Table 6 ). Among 15 cases of peripheral neuritis reported, 10 cases were caused by n-hexane and another case was exposed to 2,5-hexanedion, known for the metabolite of n-hexane ( 19 , 33 - 35 ). Others included 3 cases of mixed solvent caused by peripheral neuritis ( 24 , 28 ) and an acrylamide-induced case ( 36 ).…”

Section: Resultsmentioning

confidence: 99%

Occupational Neurological Disorders in Korea

Kim

Kang

2010

J Korean Med Sci

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The purpose of this article was to provide a literature review of occupational neurological disorders and related research in Korea, focusing on chemical hazards. We reviewed occupational neurological disorders investigated by the Occupational Safety and Health Research Institute of Korean Occupational Safety and Health Agency between 1992 and 2009, categorizing them as neurological disorders of the central nervous system (CNS), of the peripheral nervous system (PNS) or as neurodegenerative disorders. We also examined peer-reviewed journal articles related to neurotoxicology, published from 1984 to 2009. Outbreaks of occupational neurological disorder of the CNS due to inorganic mercury and carbon disulfide poisoning had helped prompt the development of the occupational safety and health system of Korea. Other major neurological disorders of the CNS included methyl bromide intoxication and chronic toxic encephalopathy. Most of the PNS disorders were n-hexane-induced peripheral neuritis, reported from the electronics industry. Reports of manganese-induced Parkinsonism resulted in the introduction of neuroimaging techniques to occupational medicine. Since the late 1990s, the direction of research has been moving toward degenerative disorder and early effect of neurotoxicity. To understand the early effects of neurotoxic chemicals in the preclinical stage, more follow-up studies of a longer duration are necessary.

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“…Concurrent or retrospective HIAs provide opportunities for identifying previously unconsidered health impacts, whereas a prospective HIA allows for prediction of positive and negative impacts and makes it possible to modify the plans prior to actual implementation of the policy [ 10 , 26 ]. HIAs in Korea have mostly dealt with occurrences of environmental disease in a retrospective manner [ 27 - 30 ]. This study, however, is different, in that it evaluated the impacts on health prior to implementation and suggested the directions the policy should take.…”

Section: Discussionmentioning

confidence: 99%

Health Impact Assessment of Free Immunization Program in Jinju City, Korea

Kim

Jeon

et al. 2012

J Prev Med Public Health

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ObjectivesThis study was conducted to assess the potential health impacts and improve the quality of the free immunization program in Jinju City by maximizing the predicted positive health gains and minimizing the negative health risks.MethodsA steering committee was established in September 2010 to carry out the health impact assessment (HIA) and began the screening and scoping stages. In the appraisal stage, analysis of secondary data, a literature review, case studies, geographic information systems analysis, a questionnaire, and expert consultations were used. The results of the data collection and analyses were discussed during a workshop, after which recommendations were finalized in a written report.ResultsIncreased access to immunization, comprehensive services provided by physicians, the strengthened role of the public health center in increasing immunization rates and services, and the ripple effect to other neighboring communities were identified as potential positive impacts. On the other hand, the program might be inaccessible to rural regions with no private clinics where there are more at-risk children, vaccine management and quality control at the clinics may be poor, and vaccines may be misused. Recommendations to maximize health gains and minimize risks were separately developed for the public health center and private clinics.ConclusionsThe HIA provided an opportunity for stakeholders to comprehensively overview the potential positive and negative impacts of the program before it was implemented. An HIA is a powerful tool that should be used when developing and implementing diverse health-related policies and programs in the community.

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A Case of Peripheral Polyneuropathy Induced by Occupational 2,5-hexanedione Exposure

Cited by 5 publications

References 0 publications

Occupational Neurologic Disorders in Korea

Occupational Neurologic Disorders in Korea

Occupational Neurological Disorders in Korea

Health Impact Assessment of Free Immunization Program in Jinju City, Korea

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