A Case of Parainfluenza Viral Myocarditis Showing Various Kinds of Conduction Disturbances

Otsu, Fumio; Otake, Minoru; Hayakawa, Hirokazu; Toyoda, Toshio; Yokota, Mannosuke

doi:10.2169/naika.67.510

Cited by 3 publications

(6 citation statements)

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“…3,4) In our patient, parainfluenza-3 viral infection was confirmed serologically and was considered to be a cause of both FT1D and fulminant myocarditis. This is the first reported case of FT1D associated with a 10)…”

Section: Discussionmentioning

confidence: 55%

“…1,2) Pathogens frequently causing viral myocarditis include Coxsackie viruses, adenovirus, and parvovirus B19, but other viruses also cause myocarditis, such as parainfluenza viruses. 3,4) Myocarditis causes heart failure and can have a fulminant clinical presentation. 5) Patients with fulminant myocarditis exhibit acute, severe hemodynamic compromise requiring hemodynamic support for survival, but can recover with minimal sequelae if they survive the initial phase.…”

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confidence: 99%

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Fulminant Type 1 Diabetes Mellitus and Fulminant Viral Myocarditis

et al. 2015

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SummaryA 35-year-old Japanese woman was admitted with coma following flu-like symptoms. She was diagnosed with diabetic ketoacidosis and fulminant type 1 diabetes (FT1D) and received intravenous infusion of insulin and saline. The next day, the ketoacidosis disappeared, and she recovered consciousness. However, extensive ST-segment elevations in the electrocardiogram appeared with a positive troponin test, and the patient developed pulmonary edema on day 3. An echocardiogram showed globally reduced wall motion of the left ventricle and mild pericardial effusion. Despite medical therapy with intravenous furosemide, carperitide, and catecholamines, her cardiac function deteriorated rapidly, with the left ventricular ejection fraction decreasing to 26% within 7 hours, and progressed to cardiogenic shock that afternoon. The patient received mechanical circulatory support for 4 days with intra-aortic balloon pumping and percutaneous cardiopulmonary support, and recovered fully from circulatory failure. A paired serum antibody test showed a significantly elevated titer against parainfluenza-3 virus, indicating a diagnosis of fulminant viral myocarditis. She was discharged on multiple daily insulin injection therapy, and her subsequent clinical course has been uneventful. In summary, we present a case of concurrent FT1D and fulminant viral myocarditis. Parainfluenza-3 viral infection was confirmed serologically and was considered to be a cause of both the FT1D and fulminant myocarditis. (Int Heart J 2015; 56: 239-244)

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Section: Discussionmentioning

confidence: 55%

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confidence: 99%

Fulminant Type 1 Diabetes Mellitus and Fulminant Viral Myocarditis

et al. 2015

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“…described the presence of HPIV‐3 RNA in the nasopharyngeal swab, pericardial fluid, and cardiac tissue in an immunocompetent child with myocarditis. Another study presented a case of HPIV myocarditis showing various types of conduction disturbance 70 . The potential pathogenicity of HPIV‐4, even in an immunocompetent child, has been shown in the form of pericardial effusion 71 .…”

Section: Methodsmentioning

confidence: 99%

The landscape of extrapulmonary manifestations of human parainfluenza viruses: A systematic narrative review

Farahmand

Malekshahi

Jabbari

et al. 2020

Microbiology and Immunology

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Human parainfluenza virus (HPIV) infection is associated with every kind of respiratory tract illnesses, including the common cold, laryngotracheobronchitis (i.e. croup), tracheobronchitis, bronchiolitis, and pneumonia, in both children and adults. Although HPIVs are common respiratory pathogens, there are increasing reports about extrapulmonary manifestations of HPIVs infection. Each of the HPIVs could produce infection of other organs (central nervous system, heart, myocardium, etc.) in all age groups who are either immunocompetent or immunocompromised. This review aimed at summarizing the available data on clinical manifestations of HPIV infection outside the respiratory tract from 1961 to 2020. The findings support the possibility of extrapulmonary infections that were thought to be due to rare host genetic or immunologic defects in infected patients. These findings highlight the fact that extrapulmonary dissemination of HPIV can occur, but the association is not clearly demonstrated. Our data support the hypothesis that HPIV infection is one of the possible causes of these alterations and may even be the direct cause in some cases.

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“…1 Amongst the viral causes of acute myocarditis, human parainfluenza virus (HPIV) infection as an aetiology is rare with only four cases reported in the literature. [2][3][4][5] Two cases of myocarditis associated with HPIV infection were diagnosed by a rise in paired serology 2 and a positive viral culture on throat swab. 4 A recent report of HPIV myocarditis demonstrated the presence of HPIV-3 ribonucleic acid (RNA) on nasopharyngeal swab, pericardial fluid and cardiac tissue.…”

Section: Why This Case Is Importantmentioning

confidence: 99%

“…Few reports have demonstrated HPIV as the aetiology of viral myocarditis. [2][3][4][5] In most of the previously reported cases (Table 1), the diagnosis was made by paired serology. Serology for HPIV however, lacks specificity due to cross reactivity directed against the envelope glycoproteins, HN and F proteins of other paramyxoviruses and hence may be difficult to interpret.…”

Section: Other Similar and Contrasting Cases In The Literaturementioning

confidence: 99%

Successful clearance of human parainfluenza virus type 2 viraemia with intravenous ribavirin and immunoglobulin in a patient with acute myocarditis

Kalimuddin

Sessions

Hou

et al. 2013

Journal of Clinical Virology

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Human parainfluenza virus (HPIV) infection as an aetiology of acute viral myocarditis is rare, with only few cases reported in the literature to date. Here we report a case of fulminant HPIV-2 myocarditis in a 47 year-old man with viraemia who was successfully treated with intravenous ribavirin and intravenous immunoglobulin (IVIG). There are currently no recommendations on the treatment of HPIV myocarditis. We are, to our knowledge, the first to report a patient with a documented HPIV-2 viraemia that subsequently cleared after the initiation of antiviral therapy. Although it is difficult to definitively attribute the patient's clinical improvement to ribavirin or IVIG alone, our case does suggest that clinicians may wish to consider initiating ribavirin and IVIG in patients with HPIV myocarditis and persistent viraemia not responding to supportive measures alone.

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A Case of Parainfluenza Viral Myocarditis Showing Various Kinds of Conduction Disturbances

Cited by 3 publications

References 0 publications

Fulminant Type 1 Diabetes Mellitus and Fulminant Viral Myocarditis

Fulminant Type 1 Diabetes Mellitus and Fulminant Viral Myocarditis

The landscape of extrapulmonary manifestations of human parainfluenza viruses: A systematic narrative review

Successful clearance of human parainfluenza virus type 2 viraemia with intravenous ribavirin and immunoglobulin in a patient with acute myocarditis

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