A Case of Panhypopituitarism with Normal Height Manifesting the Transection of the Pituitary Stalk and the Formation of the Ectopic and Eutopic Posterior Lobes

Ihara, Chihiro; Shimatsu, Akira; Tanoh, Tsutomu; Harada, Masaki; Nakamura, Tomoyuki; Imura, Hiroo

doi:10.1507/endocrine1927.68.2_81

Cited by 3 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Growth independent of GHhas been reported in some cases of craniopharyngioma, but in only one case of hypopituitarism due to PST (4). It is known that there exist some growthpromoting factors other than GHand IGF-I, and thyroid hormone, insulin, prolactin (PRL) and IGF-II play significant roles in postnatal somatic growth even without GH (1,2,7,8).…”

Section: Discussionmentioning

confidence: 99%

“…In our present patient, TSHincreased after TRH,but thyroid hormones did not. This may suggest the presence of TSHwith a low bioactivity, as in somecases of hypophysial damage (4). Insulin is known to bind to the IGF-I receptor, increase chondrogenesis, and stimulate growth without GH(1, 10).…”

Section: Discussionmentioning

confidence: 99%

“…As far as we know,there is only one previous case report on growth without GHin hypopituitarism. Ihara et al (4) reported that a panhypopituitary subject who had pituitary stalk transection (PST) on magnetic resonance imaging (MRI) attained normal stature without GHreplacement. Weherewith report another rare case of GHdeficiency whomanifested tall stature as adult even without GH.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Hypopituitary Patient who Attained Tall Stature without Growth Hormone.

et al. 1998

View full text Add to dashboard Cite

Wedescribe an unusual patient with hypopituitarism whoattained tall stature even without growth hormone (GH). A 37-year-old man was devoid of secondary sexual characteristics, but manifested tall stature with a eunuchoidal feature. Serumlevels of GH, insulin-like growth factor-I, gonadotropins and testosterone were all belownormal. GHsecretion was not enhancedby any provocative stimulus. Adrenocorticotropic hormoneincreased after administration of corticotropin releasing hormone, but not after insulin-induced hypoglycemia. Thyrotropin increased in response to thyrotropin releasing hormone, but both free T3 and T4 did not rise. Magnetic resonance imaging disclosed a transected pituitary stalk. The present patient had hypopituitarism due to perinatal problems but had grown with the aid of non-GH growth-promoting factors, which suggests that man may be able to achieve statural growth even without GH. (Internal Medicine 37: 472-475, 1998)

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Hypopituitary Patient who Attained Tall Stature without Growth Hormone.

et al. 1998

View full text Add to dashboard Cite

show abstract

The Apparent Paradox of Tall Stature with Hypopituitarism: New Insights from an Old Story

Faustini‐Fustini

Antonio

Rochira

et al. 2003

The Journal of Clinical Endocrinology & Metabolism

View full text Add to dashboard Cite

Late Onset of Adrenocortical Failure in GH Deficiency with Invisible Pituitary Stalk: A Case Report of a 48-Year-Old Japanese Man and Review of the Literature.

Makino¹,

Kawasaki²,

Irimoto³

et al. 2002

Endocr J

View full text Add to dashboard Cite

ACTH deficiency gradually develops in patients with growth hormone deficiency (GHD) who have abnormalities of the pituitary stalk on magnetic resonance imaging (MRI) following perinatal complications. We report here a rare case of GHD manifesting ACTH deficiency in middle age. A 48-year-old male patient was admitted to our hospital due to fever and hyponatremia. He was diagnosed as GHD and hypothyroidism at the age of 9, and had received lysine treatment until age 20, which was then replaced by thyroid hormone. He was not mentally retarded, but was the shortest in his class throughout his schooldays, reaching a final height of 148 cm. Hormonal examination revealed the presence of hypoadrenalism as indicated by poor responses of plasma cortisol to intravenous administration of corticotropin-releasing hormone (CRH) and insulin-induced hypoglycemia. Plasma ACTH responded well to CRH, but not to insulin-induced hypoglycemia, indicating that his hypoadrenalism was of hypothalamic origin. MRI showed an invisible pituitary stalk and relatively small pituitary gland. Since he had a perinatal abnormality, the damage around the pituitary and GHD could have originated from birth. In the literature, around 60% of GHD patients with pituitary stalk abnormalities develop hypoadrenalism due to ACTH deficiency, and more than 90% of such cases are diagnosed by age 30. We suggest that the appearance of hypoadrenalism should be carefully monitored in GHD patients with pituitary stalk abnormalities even after they reach middle age.

show abstract

A Case of Panhypopituitarism with Normal Height Manifesting the Transection of the Pituitary Stalk and the Formation of the Ectopic and Eutopic Posterior Lobes

Cited by 3 publications

References 0 publications

A Hypopituitary Patient who Attained Tall Stature without Growth Hormone.

A Hypopituitary Patient who Attained Tall Stature without Growth Hormone.

The Apparent Paradox of Tall Stature with Hypopituitarism: New Insights from an Old Story

Late Onset of Adrenocortical Failure in GH Deficiency with Invisible Pituitary Stalk: A Case Report of a 48-Year-Old Japanese Man and Review of the Literature.

Contact Info

Product

Resources

About