A case of pancreatic schwannoma showing increased FDG uptake on PET/CT

Fukuhara, Sotaro; Fukuda, Saburo; Tazawa, Hirofumi; Imaoka, Kouki; Mochizuki, Tetsuya; Hirata, Yoshihiro; Fujisaki, Seiichiro; Takahashi, Mamoru; Nishida, Toshihiro; Sakimoto, Hideto

doi:10.1016/j.ijscr.2017.05.031

Cited by 9 publications

(8 citation statements)

References 19 publications

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“…On 18F-fluorodeoxyglucose positron emission tomography (FDG-PET), elevated FDG activity in schwannomas has been reported, [90] even though they are usually benign. To date, all 5 cases of pancreatic schwannoma that underwent PET/CT had increased FDG uptake [8,17,23,29] . Recently, an increasing number of cases have undergone endoscopic ultrasound fine needle aspiration (EUS-FNA), which has greatly contributed to precise preoperative diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…To date, all 5 cases of pancreatic schwannoma that underwent PET/CT had increased FDG uptake. [8,17,23,29] Recently, an increasing number of cases have undergone endoscopic ultrasound fine needle aspiration (EUS-FNA), which has greatly contributed to precise preoperative diagnosis. Of the 12 patients with pancreatic schwannoma who underwent EUS-FNA, 9 were accurately diagnosed.…”

Section: Discussionmentioning

confidence: 99%

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Successful treatment of pancreatic schwannoma by enucleation

Zhou

Wei

et al. 2022

Medicine

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Rationale: Pancreatic schwannomas are extremely rare and are difficult to diagnose preoperatively. Over the past 50 years, only 96 cases of pancreatic schwannoma have been reported in English literature. Herein, we report a case of pancreatic schwannoma treated with enucleation.Patient concerns: A 66-year-old woman visited a local hospital due to ventosities. Ultrasonography and computed tomography revealed a pancreatic mass. She visited our hospital for further diagnosis and treatment.Diagnosis and interventions: Magnetic resonance imaging revealed a tumor in the pancreatic body, and a solid pseudopapillary tumor was considered preoperatively. During the surgery, a pancreatic mass was found growing in the pancreatic body and tail. A successful tumor enucleation was performed. The mass was 7 Â 6 Â 3 cm in size with a thin capsule. Pathological examination revealed that the tumor was mainly composed of spindle-shaped cells with a palisading arrangement and no atypia. Both hypercellular and hypocellular areas were visible. Immunohistochemical staining showed that protein S-100 was strongly positive. The tumor was diagnosed as a benign schwannoma originating from the pancreatic body and tail.Outcomes: Postoperatively, the patient showed good recovery. During the 24-month follow-up period, the patient remained well and free of complications.Lessons: Pancreatic schwannomas are extremely rare and difficult to diagnose using imaging examinations. Enucleation is a safe and efficacious treatment for exophytic pancreatic schwannomas.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Successful treatment of pancreatic schwannoma by enucleation

Zhou

Wei

et al. 2022

Medicine

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“…When pancreatic schwannoma appears as a mixed lesion of solid and cystic components, it resembles malignant pancreatic tumors and can be perceived that way even though pancreatic schwannoma is benign in the majority of cases. Some studies have shown that pancreatic schwannomas are also highly metabolic and light up on positron emission tomography-computed tomography scans, which also might be mistaken for malignancy [4,9]. This similarity might pose a risk for possible misdiagnosis and inappropriate management in some cases.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Pancreatic Schwannoma

Tambovtseva¹,

Ashraf²,

Suleiman³

et al. 2022

Cureus

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Pancreatic schwannoma is a neuroendocrine cell tumor that arises in the pancreas. It is very rare, and, to date, only fewer than 70 similar cases have been reported in the literature. Here, we present another case of this type of tumor in a 68-year-old female.In addition to describing the pancreatic schwannoma, we discuss the major challenges associated with its diagnosis and management. As such, clinically and on imaging, pancreatic schwannomas are almost indistinguishable from other cancerous or benign pancreatic tumors. Therefore, only a biopsy can definitively diagnose pancreatic schwannomas by demonstrating spindle-shaped cells with immunohistochemistry positive for S-100.Because pancreatic schwannomas are very rare, it is important to increase awareness among clinicians about this condition and inform them regarding the challenges associated with its diagnosis and management.

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“…The mean tumor size was 57.5 mm. Excluding their review, we found two case reports of pancreatic schwannoma described in the English-language literature by Ercan et al [ 5 ] and Fukuhara et al [ 6 ]. Xu et al [ 2 ] found that the most common symptom of pancreatic schwannoma is abdominal pain.…”

Section: Discussionmentioning

confidence: 99%

A Surgically Resected Pancreatic Schwannoma with Obstructive Jaundice with Special Reference to Differential Diagnosis from Other Cystic Lesions in the Pancreas

Watanabe

Araki

Ishii

et al. 2018

Case Rep Gastroenterol

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Pancreatic schwannomas are uncommon. About 60% of pancreatic schwannomas develop cystic lesions, and the differential diagnosis from other cystic pancreatic tumors is difficult. A 43-year-old man presented for evaluation of liver dysfunction detected during a medical checkup. Blood testing detected obstructive jaundice. A computed tomography scan revealed a well-defined polycystic tumor of about 5 cm at the pancreatic head. We performed surgical resection to treat the patient’s symptoms and facilitate long-term management. Histopathological examination revealed spindle-shaped cells. Immunohistochemical studies showed S100 protein expression and the absence of CD34 and c-kit protein expression. Finally, we diagnosed a schwannoma. Pancreatic schwannoma is usually asymptomatic. The present case presented with obstructive jaundice, which is reportedly a rare symptom. Pancreatic schwannomas should be considered as a differential diagnosis of pancreatic cystic tumors. Dilatation of the pancreatic duct and the 18-fluorodeoxyglucose positron emission tomography findings are important for the differential diagnosis.

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A case of pancreatic schwannoma showing increased FDG uptake on PET/CT

Cited by 9 publications

References 19 publications

Successful treatment of pancreatic schwannoma by enucleation

Successful treatment of pancreatic schwannoma by enucleation

A Rare Case of Pancreatic Schwannoma

A Surgically Resected Pancreatic Schwannoma with Obstructive Jaundice with Special Reference to Differential Diagnosis from Other Cystic Lesions in the Pancreas

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