A case of ovarian teratoma with nephroblastoma presenting spontaneous rupture

Nakabayashi, Akira; Kanno, Toshiyuki; Takahashi, Nobuko; Akizawa, Yoshika; Onizuka, Hiromi

doi:10.1111/jog.13887

Cited by 6 publications

(9 citation statements)

References 6 publications

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“…Nephroblastoma has been discovered to affect the function of unilateral or bilateral kidneys ( 33 , 34 ). Although the diagnosis and treatment of nephroblastoma has significantly improved, the mortality rate of nephroblastoma in children remains high (10.7%) ( 35 , 36 ). Thus, studying the effects of factors related to early nephroblastoma may provide a novel target and treatment method for nephroblastoma.…”

Section: Discussionmentioning

confidence: 99%

FOXO3a inhibits nephroblastoma cell proliferation, migration and invasion, and induces apoptosis through downregulating the Wnt/β‑catenin signaling pathway

Qian

Liu

2021

Mol Med Rep

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Forkhead transcription factor O subfamily 3A (FOXO3a) is an important tumor suppressor gene that is expressed in renal tissue and has been reported to be downregulated in clear cell renal cell carcinoma (CCRCC). Notably, the overexpression of FOXO3a was previously discovered to inhibit the progression of CCRCC. However, the expression levels of FOXO3a in nephroblastoma cell lines remain unknown. The present study aimed to investigate the expression levels of FOXO3a in nephroblastoma cell lines and to determine the mechanism of action of the biological functions of FOXO3a. Western blotting and reverse transcription-quantitative PCR were used to analyze the expression levels of FOXO3a in nephroblastoma cell lines. Subsequently, the effects of the overexpression of FOXO3a and the genetic knockdown of the Wnt/β-catenin signaling protein Axin-2 on the biological functions were determined through Cell Counting Kit-8, cell colony formation assays, scratch and Transwell assay and flow cytometric analysis experiments. The expression levels of FOXO3a were discovered to be downregulated in nephroblastoma cell lines. The overexpression of FOXO3a inhibited the proliferation, invasion and migration of nephroblastoma cells, while inducing apoptosis. Furthermore, the overexpression of FOXO3a downregulated the expression levels of β-catenin and Cyclin-D1 proteins involved in the Wnt/β-catenin signaling pathway. Cell proliferation and the migration and invasion ability of 17–94 cells in shRNA-Axin2-2 group were promoted. Cell apoptosis was predominantly increased by overexpressed FOXO3a, which was reversed by shRNA-Axin2-1. The biological effects of overexpressing FOXO3a on nephroblastoma were reversed after activation of Wnt/β-catenin. In conclusion, the findings of the present study suggested that FOXO3a may inhibit nephroblastoma cell proliferation, migration and invasion, while inducing apoptosis, by downregulating the Wnt/β-catenin signaling pathway. These results may provide a novel method for the early diagnosis and precise treatment of nephroblastoma.

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Section: Discussionmentioning

confidence: 99%

FOXO3a inhibits nephroblastoma cell proliferation, migration and invasion, and induces apoptosis through downregulating the Wnt/β‑catenin signaling pathway

Qian

Liu

2021

Mol Med Rep

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“…According to the previous similar cases in Table 1, two cases received fertility‐preserving surgery 1,3 . The other case showed intra‐peritoneal dissemination shortly after primary excision of a ruptured tumor, and then complete remission after second complete staging surgery with adjuvant chemotherapy 2 …”

Section: Figurementioning

confidence: 89%

“…To the best of our knowledge, immature renal tissue in ovarian teratoma is extremely rare, with only three cases being reported previously (Table 1). [1][2][3] The pathogenesis of the tumor was unclear, and various nomenclatures have been used to describe this phenomenon: immature renal tissue in teratoma, teratoma with nephroblastoma/Wilms tumor, and teratoid Wilms tumor. Coli et al suggested that immature renal tissue is generally not aggressive and should be differentiated from a true Wilms tumor, based on atypia, atypical mitoses, marked pleomorphism and expanding growth.…”

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confidence: 99%

“…1,3 The other case showed intra-peritoneal dissemination shortly after primary excision of a ruptured tumor, and then complete remission after second complete staging surgery with adjuvant chemotherapy. 2 In conclusion, ovarian teratoma may contain immature renal tissue, which could be named as an immature component instead of nephroblastoma/Wilms tumor if no atypia or invasive growth is seen, as the nomenclature would affect the clinician in the evaluation of treatment. In the absence of atypia and invasive growth, complete tumor excision with careful follow-up seems an acceptable strategy.…”

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confidence: 99%

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Immature renal tissue occurring in cystic teratoma of ovary

Hsu

Chuang

2023

The Kaohsiung J of Med Scie

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A 25-year-old, G0P0 female had bilateral cystic teratoma history and had undergone laparoscopic partial oophorectomy at the ages of 18 and 22. A right ovarian mass was found on sonography during follow-up (Figure 1A). Subsequent contrast-enhanced computed tomography showed a 5.7 cm ovarian teratoma with ascites (Figure 1B). Two months later, she suffered from progressive abdominal cramping pain and visited the emergency

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“…Currently, the pathogenesis of TWN is still controversial. Some researchers believe that majority of these tumors are pure nephroblastomas, but that only a small part of it originates from teratomas or germ cell neoplasms, 6 while some other investigators favor that TWN is thought to be aroused from extensive metaplasia of metanephric blastema. 7 Moreover, TWN has been presented in various locations.…”

Section: Discussionmentioning

confidence: 99%

A case of ovarian Teratoma with nephroblastoma presenting abdomen metastasis

Chu

Zhang

et al. 2022

Clinical Laboratory Analysis

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Nephroblastoma, also known as Wilms tumor, is a malignant neoplasm that typically accounts for more than 90% of renal tumors in children. 1 Classically, nephroblastoma frequently exhibits a polyphasic differentiation pattern with blastemal, stromal, and epithelial components. 2 Teratoma with nephroblastoma (TWN) is a rare variant of it, first described by Variend et al. in 1984. 3 According to Fernandas' criteria, the TWN should be defined as the triphasic tumor in which heterologous elements like cartilage, muscles, adipose tissue, glial tissue constituted more than 50% of the mass. 4 To the best of our knowledge, 45 cases of TWN have been reported in English literature, while only two of them were primary ovarian TWN.We recently had an additional case of an adult ovarian TWN.Due to rupture and spillage of the tumor cells, dissemination to the

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A case of ovarian teratoma with nephroblastoma presenting spontaneous rupture

Cited by 6 publications

References 6 publications

FOXO3a inhibits nephroblastoma cell proliferation, migration and invasion, and induces apoptosis through downregulating the Wnt/β‑catenin signaling pathway

FOXO3a inhibits nephroblastoma cell proliferation, migration and invasion, and induces apoptosis through downregulating the Wnt/β‑catenin signaling pathway

Immature renal tissue occurring in cystic teratoma of ovary

A case of ovarian Teratoma with nephroblastoma presenting abdomen metastasis

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