A case of oral multiple primary cancer including Spindle Cell Carcinoma

Kato, H; Nomura, Junichi; Matsumura, Yoshihiko; Yanase, Shigeaki; Miyahara, Kaori; Matsuura, Rina; Tagawa, Tetsuya

doi:10.1007/s12663-010-0054-3

Cited by 6 publications

(6 citation statements)

References 14 publications

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“…Systemic symptoms, for instance, generalized weakness, weight loss, abdominal pain, anemia, and fever were complained by selected patients (Howard et al, 2007; Shibuya et al, 2000). Twenty‐four cases had cervical lymph node metastasis upon treatment (Bavle et al, 2016; Jayaram & Elsayed, 2005; Kato et al, 2010; Munakata et al, 1998; Ohba et al, 2015; Ramesh et al, 2019; Reyes et al, 2015; Shigeta et al, 2015; Stojadinovic et al, 2002; Su et al, 2006; Wen‐cheng et al, 2005). Thirteen patients had a prior history of cancer, and 8 patients had prior oral SCC (Gorsky & Epstein, 1998; Kato et al, 2010; Okuyama et al, 2017; Xie et al, 2017).…”

Section: Resultsmentioning

confidence: 99%

“…Twenty‐four cases had cervical lymph node metastasis upon treatment (Bavle et al, 2016; Jayaram & Elsayed, 2005; Kato et al, 2010; Munakata et al, 1998; Ohba et al, 2015; Ramesh et al, 2019; Reyes et al, 2015; Shigeta et al, 2015; Stojadinovic et al, 2002; Su et al, 2006; Wen‐cheng et al, 2005). Thirteen patients had a prior history of cancer, and 8 patients had prior oral SCC (Gorsky & Epstein, 1998; Kato et al, 2010; Okuyama et al, 2017; Xie et al, 2017). Particularly, two patients had multiple oral SCC recurrences before they were diagnosed with intraoral SpCC (Kato et al, 2010; Xie et al, 2017).…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen patients had a prior history of cancer, and 8 patients had prior oral SCC (Gorsky & Epstein, 1998;Kato et al, 2010;Okuyama et al, 2017;Xie et al, 2017). Particularly, two patients had multiple oral SCC recurrences before they were diagnosed with intraoral SpCC (Kato et al, 2010;Xie et al, 2017).…”

Section: Clinical and Pathological Features Of Intraoral Spccmentioning

confidence: 99%

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Comprehensive analyses of intraoral spindle cell carcinoma: A rare disease entity revisited

Sang

Dai

et al. 2021

Oral Diseases

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Objective The present study was aimed to comprehensively characterize the epidemiological, clinicopathological characteristics, treatments, and prognosis of intraoral spindle cell carcinoma (SpCC). Materials and Methods Patients diagnosed with intraoral SpCC at our institution in the past 15 years (2005–2019) were screened from inpatient disease registry. All relevant data concerning patients with intraoral SpCC were retrieved. Previous reports about intraoral SpCC with adequate clinicopathological data in both English literature and Chinese literature were collected. Eligible cases were further reviewed and pooled for statistical analyses. Results Six patients (5 females and 1 male; average age: 59 years) with intraoral SpCC were histopathologically diagnosed and surgically treated at our institution. The literature review identified another 63 published cases from 34 articles. Most cases were presented in the fifth to seventh decade of life with a male preponderance. Gingiva (23/69, 33.3%) was the most common site followed by the tongue (19/69, 27.5%) and buccal mucosa (8/69, 11.6%). Complete surgical ablation remains the primary treatment option. Tumor size, pathological grades, cervical node metastasis, and distant metastasis were significantly associated with reduced survival. Conclusions Intraoral SpCC is an uncommon and aggressive malignancy with dismal prognosis. Much attention and effort are needed to characterize this rare entity and improve its clinical outcomes.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Clinical and Pathological Features Of Intraoral Spccmentioning

confidence: 99%

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Comprehensive analyses of intraoral spindle cell carcinoma: A rare disease entity revisited

Sang

Dai

et al. 2021

Oral Diseases

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“…5,12,16,28 The utility of adjuvant radiotherapy in HNSpCC has been doubted because studies have reported high mortality in irradiated patients. 12,16,17,22,24,28,29,37,38,[55][56][57][58][59][63][64][65][66][67][68][69][70][71] Of importance, many studies demonstrating disappointing responses to radiotherapy were either of limited size and scope, sampled nonrepresentative populations, or failed to include data necessary for making definitive inferences about treatment and outcomes. 6 To our knowledge, our study is the first to report that treatment with surgery + radiotherapy and surgery + chemoradiotherapy both provide independent survival benefits in HNSpCC when compared with treatment with surgery alone, after adjusting for patient, tumor, and treatment characteristics.…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of head and neck spindle cell carcinoma

et al. 2022

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Background Our study investigates the prognostic significance of spindle cell histology on overall survival (OS) of conventional head and neck squamous cell carcinoma (HNSCC). Methods The 2004 to 2017 National Cancer Database was queried for patients with head and neck spindle cell carcinoma (HNSpCC) (n = 1572) or HNSCC (n = 242 697) of the oral cavity, major salivary glands, sinonasal tract, oropharynx, hypopharynx, and larynx treated with curative intent. Results Patients with HNSpCC presented more frequently with higher‐grade tumors and cN0 disease than those with HNSCC (p < 0.001). In the oral cavity, the HR for death for SpCC compared with SCC was 1.33 (p < 0.001). In the oropharynx, the HR for death for SpCC compared with SCC was 1.47 (p = 0.028). Conclusions After adjusting for patient, tumor, and treatment characteristics, SpCC histology had an independent adverse prognostic effect on OS in the oral cavity and oropharynx. SpCC histology does not necessarily portend poorer survival in all HNSCC. Level of Evidence: 4.

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“…The overall survival of SpCC is poorer than SCC [12]. Surgical resection with neck dissection is accepted as the best treatment of choice in the oral cavity [4, 7] and is aimed at controlling local and distant recurrence [11].…”

Section: Discussionmentioning

confidence: 99%

ecancermedicalscience

Biradar

Dantkale

Abhange

et al.

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Spindle cell carcinoma (SpCC), a rare, aggressive variant of squamous cell carcinoma (SCC), is characterised by proliferation of epithelial and mesenchymal components. It is important to diagnose this variant of SCC, because of its tendency to recur and early metastasis. It accounts for 1% of all tumours in the oral cavity. In this paper, we have reported a case of SpCC of the tongue in a 65-year-old male who presented with a polypoidal growth over the lateral border of his tongue with a short history of one month. Immunohistochemical expression of cytokeratin was strongly positive in the epithelial component and focally in the spindle cell component. The spindle cell component showed a strong positivity for vimentin.

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A case of oral multiple primary cancer including Spindle Cell Carcinoma

Cited by 6 publications

References 14 publications

Comprehensive analyses of intraoral spindle cell carcinoma: A rare disease entity revisited

Comprehensive analyses of intraoral spindle cell carcinoma: A rare disease entity revisited

Prognostic significance of head and neck spindle cell carcinoma

ecancermedicalscience

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