A case of non-fluent/agrammatic variant of primary progressive aphasia with logoclonia

Abstract

We report a case of non-fluent/agrammatic variant of primary progressive aphasia in a 79-year-old right-handed man who was admitted with a 5-year history of non-fluent speech and apraxia of speech. He also presented with agrammatism and logoclonia (the meaningless repetition of the middle or final syllable of a word). Furthermore, brain MRI revealed atrophy of the bilateral frontal and temporal lobes, while N-isopropyl-p-123 I-iodoamphetamine single-photon emission computed tomography (SPECT) revealed relative hypoperfusion in the right basal ganglia. In addition, dopamine transporter SPECT revealed a decrease in specific binding ratio values, indicating neural dopamine dysfunction, which led to his diagnosis of progressive non-fluent aphasia with logoclonia. Logoclonia is a severe linguistic dysfunction usually observed in the advanced stages of Alzheimer's disease. However, based on the clinical course and cerebrospinal fluid evaluation results, our patient did not show any features of Alzheimer 's disease. Thus, logoclonia might be associated with lesions involving the basal ganglia, right hemisphere, and left frontotemporal lobe.

Dysgraphia Phenotypes in Native Chinese Speakers With Primary Progressive Aphasia

“…30,37,38 Similar lexical-level phonologically plausible errors have previously been reported in Japanese individuals with svPPA who inaccurately used logographic Kanji homophones as phonograms when completing Kanji dictation tasks. [39][40][41] Voxel-based morphometry (VBM) analysis revealed that the homophone and phonologically alike paragraphias were negatively correlated with bilateral anterior temporal gyri, which are brain regions known to be critical for semantic processing and are typically affected in individuals with svPPA. [42][43][44] This is consistent with our finding that the frequency of factor 1 errors is strongly correlated with the language tasks targeting semantic knowledge.…”

“…accurately portray the dysgraphia phenotype of Chinese and Japanese individuals with svPPA. [39][40][41] A broader depiction that encompasses the various phonologically plausible writing errors formed by both lexical and sublexical phonograms will increase the generalizability of the svPPA diagnostic criteria. Similarly, incorporating writing system-specific dysgraphia phenotypes, such as orthographically similar and orthographic selection writing errors, can potentially enhance the classification of PPA variants in the respective languages.…”