We review the current status of studies of large-scale structure in the X-ray Universe.After motivating the use X-rays for cosmological purposes, we discuss the various approaches used on different angular scales including X-ray background multipoles, cross-correlations of the X-ray background with galaxy catalogues, clustering of X-ray selected sources and small-scale fluctuations and anisotropies in the X-ray background. We discuss the implications of the above studies for the bias parameter of X-ray sources, which is likely to be moderate for X-ray selected AGN and the X-ray background (b X ∼ 1 − 2). We finally outline how all-sky X-ray maps at hard X-rays and medium surveys with large sky coverage could provide important tests for the cosmological models.