A Case of Neglected, Recurrent Adenoid Cystic Carcinoma of Parotid Gland

Low, Adeline; Kadir, Azida Juana; Wong, Kum Thong; Choo, May May

doi:10.1097/iop.0000000000001947

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“…The parotid gland is the most commonly affected major salivary gland, followed by the submandibular [ 2 ]. The tumor generally causes enlargement of the involved gland in the form of a lump or nodule in the periauricular and/or infra-auricular areas, or significant swelling of the affected side of the face sometimes can reach an extensive size if neglected [ 10 ]. Furthermore, SACC of the parotid has been reportedly associated with an odontogenic-like pain referring to the maxillary sinus and sialolithiasis [ 11 , 12 ].…”

Section: Resultsmentioning

confidence: 99%

“…Salivary adenoid cystic carcinoma is a histopathological subtype of the basaloid malignancies that affect the exocrine glands in the head and neck, mainly the salivary glands. The cancer was previously known as “cylindroma” due to its histologic pattern that consists of cylinders of glandular epithelial cells immersed in a dense hyaline stroma [ 10 ]. There are three main histopathological patterns for this tumor: cribriform, tubular, and solid.…”

Section: Resultsmentioning

confidence: 99%

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Adenoid Cystic Carcinoma of Salivary Glands: A Ten-Year Review and an Assessment of the Current Management, Surgery, Radiotherapy, and Chemotherapy

Saleh

Ukwas

2023

International Journal of Otolaryngology

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Adenoid cystic carcinoma (ACC) is a rare cancer that arises from the salivary glands and other sites in the body, such as the lung and breast. Although the tumor accounts for 10% of all salivary gland malignancies, it only accounts for 1% of head and neck malignancies. It can affect both major and minor salivary glands; here, it is called salivary gland adenoid cystic carcinoma or SACC, with a slight predilection to the latter, and commonly manifests between the 6th and 7th decades of life. The disease also shows a slight female predilection, with a reported female to male ratio of 3 : 2. Lesions of SACC are often insidious and slow-growing, and symptoms such as pain and altered sensation are frequently associated with advanced stages of the disease. Salivary adenoid cystic carcinoma is characterized by perineural invasion (PNI), a distinctive feature that potentially plays a significant role in the tumor’s relapse and recurrence, which is approximately 50%. The disease is not prevalent, and its etiopathogenesis is poorly understood, although several genetic patterns and biomarkers have been linked to its initiation and/or progression. The discovery of these mutations and biomarkers has encouraged several clinical studies to use therapeutic agents to target the specific receptors on the cancer cells to potentially prevent further proliferation of the tumor cells and metastasis of the disease. Diagnosis of SACC is often challenging and frequently requires a combination of clinical examination, imaging, and histopathology. Management of SACC is primarily surgical excision, while radiotherapy has shown to be effective in improving local control in cases with microscopic residual disease. However, treatment of recurrent or metastatic tumors by radiotherapy with or without chemotherapy has so far shown limited success. The aim of this thesis is to provide an update of literature on SACC with a particular focus on the latest management approaches and future trends.

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