A Case of Myocarditis and Near-Lethal Arrhythmia Associated With Interleukin-2 Therapy

Wu, Stephanie; Sarcon, Anna; Do, Khuyen; Shinbane, Jerold S.; Doshi, Rahul N.; Herle, Helga Van

doi:10.1177/2324709617749622

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…IL-2 has also been associated with the recurrence of AF in patients undergoing catheter ablation (5). In addition, high-dose IL-2 therapy has been significantly associated with cardiac toxicities in patients with cancer, often resulting in lethal arrhythmias (6)(7)(8). However, the underlying mechanism of IL-2 in the pathogenesis of CAs still remains unclear.…”

Section: Introductionmentioning

confidence: 99%

miR-190a-5p Partially Represses the Abnormal Electrical Activity of SCN3B in Cardiac Arrhythmias by Downregulation of IL-2

Zhang

Chen

et al. 2022

Front. Cardiovasc. Med.

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Cardiac arrhythmias (CAs) are generally caused by disruption of the cardiac conduction system; interleukin-2 (IL-2) is a key player in the pathological process of CAs. This study aimed to investigate the molecular mechanism underlying the regulation of IL-2 and the sodium channel current of sodium voltage-gated channel beta subunit 3 (SCN3B) by miR-190a-5p in the progression of CAs. ELISA results suggested the concentration of peripheral blood serum IL-2 in patients with atrial fibrillation (AF) to be increased compared to that in normal controls; fluorescence in situ hybridization indicated that the expression of IL-2 in the cardiac tissues of patients with AF to be upregulated and that miR-190a-5p to be downregulated. Luciferase reporter assay, quantitative real-time-PCR, and whole-cell patch-clamp experiments confirmed the downregulation of IL-2 by miR-190a-5p and influence of the latter on the sodium current of SCN3B. Overall, miR-190a-5p suppressed the increase in SCN3B sodium current caused by endogenous IL-2, whereas miR-190a-5p inhibitor significantly reversed this effect. IL-2 was demonstrated to be directly regulated by miR-190a-5p. We, therefore, concluded that the miR-190a-5p/IL-2/SCN3B pathway could be involved in the pathogenesis of CAs and miR-190a-5p might acts as a potential protective factor in pathogenesis of CAs.

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Section: Introductionmentioning

confidence: 99%

miR-190a-5p Partially Represses the Abnormal Electrical Activity of SCN3B in Cardiac Arrhythmias by Downregulation of IL-2

Zhang

Chen

et al. 2022

Front. Cardiovasc. Med.

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“…70 Additionally, IL-2 has been associated with an upregulation of SCN3B expression and a resultant increase in sodium current density. 71 Myocarditis and near fatal arrhythmias during high dose IL-2 therapy for metastatic renal cancer were recently reported, 72 which reinforces the potential use of IL-2 levels as a marker for arrhythmias in Chagasic patients.…”

Section: Autoimmunity and Inflammation As Predictive Markers Of Sudde...mentioning

confidence: 70%

Treatment of Chronic Chagasic Patients: Is Killing the Parasite the Only Option?

Rodríguez-Angulo

2018

EMJ Cardiol

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Chagas disease is a tropical illness characterised by arrhythmias, heart failure, and eventually death. In approximately 10–30% of patients, chronic disease appears 10–30 years after infection onset. One of the biggest challenges for treatment is how to manage disease progression during the non-symptomatic phase to avoid the most life-threatening consequences of Chagas disease. The aim of this review is to evaluate the empirical rationale for an alternative therapy based on pathophysiological mechanisms that lead to chronic cardiac pathology and that have the possibility of evaluation through serological markers. The author identifies L-arginine serum levels, IL-2, and short-form Cha autoantibodies as possible markers for Chagas disease and discusses the reports regarding the therapeutic potential of amiodarone and angiotensin-converting enzyme inhibitors to modulate the electrophysiological, inflammatory, and vascular disturbances that lead to symptomatic Chagas disease. This review considers this discussion to improve the comprehension of therapeutic alternatives based on the vast literature detailing Chagas disease’s pathophysiology.

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Pathophysiology and Mechanisms of Fulminant Myocarditis

Chen

Wang

2022

Fulminant Myocarditis

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A Case of Myocarditis and Near-Lethal Arrhythmia Associated With Interleukin-2 Therapy

Cited by 4 publications

References 12 publications

miR-190a-5p Partially Represses the Abnormal Electrical Activity of SCN3B in Cardiac Arrhythmias by Downregulation of IL-2

miR-190a-5p Partially Represses the Abnormal Electrical Activity of SCN3B in Cardiac Arrhythmias by Downregulation of IL-2

Treatment of Chronic Chagasic Patients: Is Killing the Parasite the Only Option?

Pathophysiology and Mechanisms of Fulminant Myocarditis

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