A case of multiple myeloma initially presenting as hematemesis

Zhou, Hai Bo

doi:10.5152/tjg.2018.17710

Cited by 4 publications

(2 citation statements)

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“…Among patients with systemic amyloidosis, gastrointestinal tract involvement is very common [17]. However, only a small number of cases describing amyloidosis-induced gastrointestinal complications as the presenting symptom of MM have been reported [2][3][4][5][6][7][8][9][10][11]. In a review from the Mayo Clinic, symptomatic gastrointestinal amyloidosis had a 1% incidence in primary systemic amyloidosis [18].…”

Section: Discussionmentioning

confidence: 99%

“…Gastrointestinal (GI) amyloidosis is a rare and complex complication of MM. Only a small number of cases describing amyloidosisinduced gastrointestinal complications as the presenting symptom of MM have been reported [2][3][4][5][6][7][8][9][10][11]. Furthermore, previous studies have not described the many similarities between gastric amyloidosis and gastric cancer, including the clinical presentation and both the endoscopic and microscopic appearances.…”

Section: Introductionmentioning

confidence: 99%

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A case report of gastric amyloidosis due to multiple myeloma mimicking gastric cancer

Xiao

Qing

et al. 2020

BMC Gastroenterol

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Background: Gastrointestinal (GI) amyloidosis is a rare complication of multiple myeloma (MM). Due to its nonspecific clinical presentation and endoscopic appearance, an early and accurate diagnosis of GI amyloidosis is difficult. Here, we report a case of GI amyloidosis due to MM, which initially presented as GI manifestations mimicking gastric cancer. Case presentation: A 68-year-old woman presented to the hospital with a 6-month history of anemia, coupled with a recent onset of poor appetite and vomiting for 10 days. Esophagogastroduodenoscopy revealed a gastric antrum mucosal bulge that appeared on visual inspection to be a tumor. As a result, gastric cancer was suspected. However, gastric antrum biopsies demonstrated mild chronic superficial gastritis and esophageal biopsies demonstrated moderate-to-severe atypical hyperplasia of the squamous epithelium. A second endoscopy revealed massive gastric retention and a gastric antrum mucosal bulge with surface erosion. Ultimately, an upper GI tract biopsy demonstrating positive Congo red staining and a bone marrow biopsy indicating plasmacytosis confirmed the diagnosis of gastric amyloidosis due to MM. Conclusion: This case demonstrates that MM should be considered in patients with nonspecific GI manifestations, and in such cases, a biopsy with Congo red staining should be considered to confirm GI amyloidosis. Early detection of GI amyloidosis will ultimately improve outcomes for these rare patients.

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