A Case of Multicentric Glioblastoma over Three Independent Regions

Abstract

We present multicentric glioblastomas radiologically mimicking metastatic tumors. A 57-year-old female presented with multiple brain masses accompanied by generalized seizures. Since there was no primary lesion considered to be the origin, the patient underwent craniotomy to remove the mass. The mass was pathologically diagnosed as glioblastoma, IDH-wildtype. When we found a multicentric tumor mass in the brain, a metastatic tumor was first suspected, and radiotherapy without surgical resection was believed to be acceptable. However, glioblastoma, which requires intensive chemoradiotherapy, rarely demonstrates multiple lesions as in the presented case. Therefore, surgical resection should be considered to make a diagnosis and treat multiple brain tumors, especially in cases with no certain primary lesion.

The Role of Genetic Analysis in Distinguishing Multifocal and Multicentric Glioblastomas: An Illustrative Case

“…Furthermore, analyzing genetic mutations in each lesion is considered useful for understanding the process of their development [ 8 ]. Many previous reports have described patients with two lesions, patients with three or more lesions being extremely rare [ 9 , 10 ]. Therefore, the present report, which describes comprehensive analysis of three lesions, is of considerable interest.…”