A Case of Multicentric Castleman's Disease Presenting with Follicular Bronchiolitis

Hwangbo, Yup; Cha, Seung‐Ick; Lee, Yong Hoon; Lee, So Yeon; Seo, Hyewon; Oh, Serim; Kim, Minjung; Choi, Sun Ha; Park, Tae In; Shin, Kyung-Min

doi:10.4046/trd.2013.74.1.23

Cited by 6 publications

(11 citation statements)

References 11 publications

(23 reference statements)

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“…Follicular bronchiolitis arises as a result of altered immune response of the bronchial associated lymphoid tissue to an immune stimulus. In addition to the causes listed in Table 1 , it has been reported in Legionella pneumophila infection, prolonged exposure to polyethylene-flock, primary ciliary dyskinesia, and multicentric Castleman disease [ 7 – 10 ]. Adults are more commonly affected, but it also occurs in children, where its cause is usually unknown [ 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

Follicular Bronchiolitis in a Nigerian Female Child: A Case Report and Review of the Literature

Ikeri

Umerah

Ugwu

et al. 2016

Case Reports in Pediatrics

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Small airways diseases are not uncommon in childhood. They account for about 28.4% of hospital admissions for lower respiratory tract infections in South West Nigeria, most of which are due to respiratory syncytial virus (RSV) infection. Noninfectious causes of small airways diseases, on the other hand, are poorly recognized and rarely feature in the differential diagnoses of chronic/recurrent lower respiratory tract disease in our environment. We present a case of follicular bronchiolitis in a 2.5-year-old Nigerian female who had left upper lobectomy on account of recurrent cough and progressive shortness of breath.

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Section: Discussionmentioning

confidence: 99%

Follicular Bronchiolitis in a Nigerian Female Child: A Case Report and Review of the Literature

Ikeri

Umerah

Ugwu

et al. 2016

Case Reports in Pediatrics

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“…Mass in various locations [ 4 - 6 , 32 - 34 ], pleural effusion [ 12 , 35 ], bronchiolitis [ 9 , 14 , 36 ] and diffuse lung shadows [ 6 , 15 , 23 , 24 ] had been reported in cases with intrathoracic CD. Although masses could be found in the hilum [ 6 ], mediastinum [ 6 , 37 - 39 ], intercostal spaces [ 4 , 5 , 40 ], pleura [ 12 ], chest wall [ 32 , 33 ], trachea [ 8 , 34 ], lungs [ 6 , 41 ], et al, most of the reported masses were located in the hilum or mediastinum, and there was only rare case report(s) showing masses in other intrathoracic places.…”

Section: Discussionmentioning

confidence: 99%

“…Follicular bronchiolitis and BO were the reported bronchiolitis in CD cases [ 9 , 14 , 36 ]. Only Hwangbo et al reported follicular bronchiolitis in CD cases [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…Follicular bronchiolitis and BO were the reported bronchiolitis in CD cases [ 9 , 14 , 36 ]. Only Hwangbo et al reported follicular bronchiolitis in CD cases [ 14 ]. But there were some other studies showing the LIP or LIP-like changes in CD cases [ 6 , 23 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…But there were some other studies showing the LIP or LIP-like changes in CD cases [ 6 , 23 , 24 ]. Follicular bronchiolitis and LIP were considered to be on the same spectrum of the disease and the distinction is based on the extent and distribution of the lymphocytic infiltration [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

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Clinical spectrum of intrathoracic Castleman disease: a retrospective analysis of 48 cases in a single Chinese hospital

Luo

Huang

et al. 2015

BMC Pulm Med

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BackgroundThorax is the common place to develop Castleman disease (CD), but there is no systemic clinical analysis for intrathoracic CD.MethodsWe conducted a retrospective analysis of 48 intrathoracic CD patients with definite pathological diagnosis who were hospitalized between 1992 and 2012 in a Chinese tertiary referral hospital.ResultsThe study included 16 cases with unicentric CD (UCD) and 32 cases with multicentric CD (MCD). UCD were younger than MCD (30.5y vs 41.6ys, P < 0.05). MCD were more symptomatic (50% vs 96.9%, P < 0.001) and sicker than UCD, including more fever, hepatomegaly and/or splenomegaly and hypoalbuminemia. All of UCD showed solitary mass in various sites and two of them were complicated by small pleural effusion. In the MCD group, their chest CT showed obvious lymphadenopathy in the hilum and/or mediastinum (100%), diffuse parenchymal lung shadows (43.75%), pleural effusion (40.6%), mass in the mediastinum (6.25%) or hilum (3.12%) and bronchiolitis obliterans (BO) (3.12%). Besides LIP-like images, multiple nodules of different size and sites, patchy, ground-glass opacities and consolidation were showed in their chest CT. Surgery were arranged for all UCD for diagnosis and treatment and all were alive. In MCD group, superficial lymph nodes biopsies (21 cases), surgery biopsy (9 cases) and CT-guided percutaneous lung biopsy (2 cases) were performed. Hyaline vascular (HV) variant were more common in the UCD group (75% vs 37.5%, P < 0.05). In MCD group, 28 cases were prescribed with chemotherapy, one refused to receive therapy and the rest three were arranged for regular follow-up. Among MCD, 18 cases was improved, 7 cases was stable, 4 cases lost follow-up and 3 cases died.ConclusionsIntrathoracic MCD was more common than UCD in our hospital. MCD was older, more symptomic and sicker than UCD. HV variant were more common in UCD. All of UCD showed mass in various intrathoracic locations and surgery resection was performed for all and all were alive. Mass, pleural effusion, BO and diffuse pulmonary shadows, including LIP-like images, multiple nodules of different size and sites, patchy, GGO and consolidations were showed in our MCD. Most of MCD cases were arranged with chemotherapy and their prognosis were worse than UCD’s.

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The Clinical Characteristics and Outcomes of Follicular Bronchiolitis in Chinese Adult Patients

Zhao

et al. 2018

Sci Rep

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Follicular bronchiolitis (FB) is a rare interstitial lung disease (ILD) and has been reported in diverse clinical contexts. Six FB patients demonstrated by surgical lung biopsy (SLB) were reviewed between 2009 and 2017 from Nanjing Drum Tower Hospital in China. The average age of subjects was 42 years old (range: 31–55 years). The clinical symptoms were very mild. The laboratory findings showed elevated Erythrocyte sedimentation rate (ESR) and serum globulin and anemia. Pulmonary function tests were normal in four cases. Five cases had underlying diseases, such as, Sjo¨gren’s syndrome, multi-centric castlemans’ disease, idiopathic pneumonia with autoimmune features and abscess. Five cases presented as interstitial lung disease (ILD) on chest imaging with centrilobular or peribronchiolar nodules, ground glass opacities, interlobular septal thickening, cysts and bronchiectasis. Isolated mass was in one patient. The histopathology suggested the changes of FB in all subjects. Prednisone and/or cyclophosphamide were used in four cases, one did the surgery and the other was clinically monitored. All cases were alive at the end of follow up. The adult patients of FB usually have mild symptoms, ILD and underlying diseases. The definite diagnosis needs SLB. The prognosis is depended on their underlying conditions.

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A Case of Multicentric Castleman's Disease Presenting with Follicular Bronchiolitis

Cited by 6 publications

References 11 publications

Follicular Bronchiolitis in a Nigerian Female Child: A Case Report and Review of the Literature

Follicular Bronchiolitis in a Nigerian Female Child: A Case Report and Review of the Literature

Clinical spectrum of intrathoracic Castleman disease: a retrospective analysis of 48 cases in a single Chinese hospital

The Clinical Characteristics and Outcomes of Follicular Bronchiolitis in Chinese Adult Patients

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