“A case of mobile giant left atrial thrombus which vascularized with coronary arteries in severe mitral valve stenosis,” published in Cardiovascular Revascularization Medicine 2010;11(2):71–138

Lazar, Alexandra A.; Aszalos, Andor; Ober, Camelia; Encică, Svetlana; Scridon, Traian; Iancu, Adrian Corneliu

doi:10.1016/j.carrev.2010.08.004

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…Interestingly, the occurrence of neovascularity and fistula formation from the coronary arteries to the LA, as documented in both retrospective studies and case reports, highlights a complex aspect of atrial thrombosis in patients with mitral valve disease [13][14][15][16][17][18]. The precise mechanism underlying fistular formation and neovascularization remains unclear; however, numerous studies have suggested that neovascularity and the development of fistulas from the coronary arteries to the LA are commonly associated with organized atrial thrombosis in patients afflicted with mitral valve disease.…”

Section: Discussionmentioning

confidence: 98%

An Unusual Case of Cardiac Mass: A Multimodal Approach in Diagnosis and Treatment

Rankovic-Nicic,

Dragicevic-Antonic,

Antonic

et al. 2024

Healthcare

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Diagnosing intracardiac masses poses a complex, multimodal challenge. We present the case of a 72-year-old woman with a history of rheumatic fever leading to mitral stenosis and a previous mitral valve commissurotomy who reported fatigue, weakness, and palpitations over the past three months. Echocardiography revealed a tumor (53 × 40 mm) in the enlarged left atrium, attached by a wide base to the left atrium wall, exhibiting variable densities. Computerized tomography identified a heterodense mass (53 × 46 × 37 mm) with similar attachments. Angiography showed two branches from the circumflex artery intricately associated with the mass. Despite unsuccessful embolization of the mass’ blood supply, surgical intervention including mitral valve replacement, tricuspid valve annuloplasty, and tumor removal was pursued. Pathohistological analysis confirmed the mass as a thrombus. During the postoperative follow-up, the patient presented with no complaints. Follow-up echocardiography indicated the normal function of the mechanical mitral valve prosthesis and the absence of intracardiac masses. While it remains unknown whether this neovascularization is specific to patients with severe mitral valve disease, this case highlights the diagnostic challenges of differentiating between thrombi and tumors in the context of mitral valve disease. It illustrates the critical role of multimodal imaging in elucidating the anatomical and functional relationships within the heart, thereby guiding accurate diagnosis and effective treatment.

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Section: Discussionmentioning

confidence: 98%

An Unusual Case of Cardiac Mass: A Multimodal Approach in Diagnosis and Treatment

Rankovic-Nicic,

Dragicevic-Antonic,

Antonic

et al. 2024

Healthcare

View full text Add to dashboard Cite

show abstract

“…46 This phenomenon was also described in another retrospective analysis as well as several case re-ports. 34,[47][48][49][50] Whether this neovascularization is specific to patients with severe mitral valve disease is unknown but has not been reported in patients without. This potentially explains the peripheral contrast enhancement observed in our second patient.…”

Section: Discussionmentioning

confidence: 99%

Left Atrial Thrombi Masquerading as Myxomas: Mini Case Series and Literature Review

Mahmoud

Haynos

Rollor

2020

CASE

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“…Thrombi in mitral stenosis, even in the absence of AF, appear to have a much more frequent location out of the left atrial appendage, and being much more often "giant", even in recent literature [23][24][25][26][27][28][29][30][31] . Attempts have been made in finding predictors of its formation outside of or in addition to the classical risk factors [32][33][34][35][36] , but with uncertain results.…”

Section: Thromboembolic Risk In Mitral Stenosis With or Without Atrimentioning

confidence: 99%

Non-vitamin K antagonist oral anticoagulants in atrial fibrillation accompanying mitral stenosis: the concept for a trial

Caterina

2015

Europace

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Patients at thromboembolic risk with non-valvular atrial fibrillation (AF) can now be managed either with a vitamin K antagonist (VKA) or with a fixed dose of a non-VKA oral anticoagulant (NOAC), while patients with valvular AF have been restricted to VKAs on the basis of a potentially higher risk and different mechanism of thrombosis, and the lack of sufficient data on the efficacy of NOACs. The terms 'non-valvular AF' and 'valvular AF' have not been however consistently defined. 'Valvular' AF has included any valvular disorder, including valve replacement and repair. In AF with rheumatic mitral disease, observational studies strongly suggest that VKA treatment is valuable. These patients have not been included in NOAC trials, but there is also no stringent argument to have excluded them. This is at sharp variance from patients with mechanical valves, also excluded from the pivotal Phase III trial comparing warfarin with NOACs, but in whom a single Phase II trial of dabigatran etexilate against VKA treatment was stopped prematurely because of increased rates of thromboembolism as well as increased bleeding associated with dabigatran. Until more data are available, such patients should be therefore managed with VKAs. We here propose an open-label randomized trial of one of the NOACs against the best of treatment available in regions of the world in which rheumatic heart disease is still highly prevalent, aiming at showing the superiority of the NOAC used against current standard treatment.

show abstract

“A case of mobile giant left atrial thrombus which vascularized with coronary arteries in severe mitral valve stenosis,” published in Cardiovascular Revascularization Medicine 2010;11(2):71–138

Cited by 3 publications

References 7 publications

An Unusual Case of Cardiac Mass: A Multimodal Approach in Diagnosis and Treatment

An Unusual Case of Cardiac Mass: A Multimodal Approach in Diagnosis and Treatment

Left Atrial Thrombi Masquerading as Myxomas: Mini Case Series and Literature Review

Non-vitamin K antagonist oral anticoagulants in atrial fibrillation accompanying mitral stenosis: the concept for a trial

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